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https://www.tandfonline.com/doi/abs/10.1080/03639045.2019.1628770
The most common route for protein delivery, parenteral, has been focused on parenteral solution and lyophilization as formulation strategy. Additionally, new drug delivery and half-life extension approaches will further the reach of this unique class of molecules. Efforts are underway to explore the area with new technologies and development.Author: Divisha Jain, S. Shahe Mahammad, Pirthi Pal Singh, Ravinder Kodipyaka
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841609/
A Parenteral Protein Decision Support System Improves Protein Delivery In Preterm Infants: A Randomized Clinical TrialAuthor: Mhd Wael Alrifai, David P. Mulherin, Stuart T. Weinberg, Li Wang, Christoph U. Lehmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130463/
Colloidal drug delivery systems have gained increasing popularity due to their enormous applications in protein and peptide delivery. Colloidal carriers such as microparticles, liposomes and nanoparticles are widely investigated for the parenteral delivery of protein and peptide therapeutics [9,53,54]. Advantages of these carrier systems include protection of sensitive proteins, prolonged release, reduction of …Author: Ashaben Patel, Kishore Cholkar, Ashim K Mitra
https://www.sciencedirect.com/science/article/pii/B9780123849649000116
Therefore, most marketed products of protein therapeutics are designed for parenteral delivery. However, the parenteral P/P delivery suffers from such disadvantages as requiring skilled personal to ensure proper administration, frequent administration due to short half-life in vivo, a lack of site specificity precipitating various side effects, and immunogenicity at the injection site, thus leading to poor patient …Author: Himanshu Agrawal, Nipa Thacker, Ambikanandan Misra
https://www.pharmatutor.org/articles/review-parenteral-controlled-drug-delivery-system
The Parenteral administration route is the most effective and common form of delivery for active drug substances with metabolic bio-availabilities drug for which the bio-availability in limited by high first pass metabolism effect of other physicochemical limitation and for drugs with a narrow therapeutic index.
https://clinicalgate.com/parenteral-drug-delivery/
Parenteral drug delivery. Key points. • Parenteral preparations are administered to a patient by injection. • The medicine may be injected into the vascular system, into muscle or soft tissue to provide a systemic action, or into an anatomical space such as a joint or …
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