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https://www.sciencedirect.com/science/article/pii/S0939641105003383
The main purpose of this study was to prepare lipid-based self-microemulsifying drug delivery system (SMEDDS) to improve peroral bioavailability of silymarin. SMEDDS was a system consisting of silymarin, Tween 80, ethyl alcohol, and ethyl linoleate.Author: Wei Wu, Yang Wang, Li Que
https://www.sciencedirect.com/science/article/abs/pii/S0939641105003383
The main purpose of this study was to prepare lipid-based self-microemulsifying drug delivery system (SMEDDS) to improve peroral bioavailability of silymarin. SMEDDS was a system consisting of silymarin, Tween 80, ethyl alcohol, and ethyl linoleate. Particle size change of the microemulsion was evaluated upon dilution with aqueous media and loading with incremental amount of silymarin. In vitro release …Author: Wei Wu, Yang Wang, Li Que
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902333/
The bioavailability results indicated that the oral absorption of silymarin SMEDDS was enhanced about 2.2-fold compared with the hard capsule in fasted dogs. It could be concluded that SMEDDS would be a promising drug delivery system for poorly water-soluble drugs by the oral route.Author: Xinru Li, Quan Yuan, Yanqing Huang, Yanxia Zhou, Yan Liu
https://www.researchgate.net/publication/7251795_Enhanced_bioavaiability_of_silymarin_by_self-microemulsifying_drug_delivery_system
The main purpose of this study was to prepare lipid-based self-microemulsifying drug delivery system (SMEDDS) to improve peroral bioavailability of silymarin. SMEDDS was a system consisting of silymarin, Tween 80, ethyl alcohol, and ethyl linoleate.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622520/
Oct 22, 2015 · The improved oral bioavailability of SM with the liposome preparations may be due to the liposomes containing a bile salt that interacted with phospholipids in the GI tract to form mixed micelles that play important roles in enhancing the absorption of lipids and poorly water-soluble drugs by bile salt monomers.Author: Gang Yang, Yaping Zhao, Yongtai Zhang, Beilei Dang, Ying Liu, Nianping Feng
https://www.ncbi.nlm.nih.gov/pubmed/22026156
Optimized self-microemulsifying drug delivery systems (SMEDDS) for enhanced oral bioavailability of astilbin. Mezghrani O(1), Ke X, Bourkaib N, Xu BH. Author information: (1)Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China. [email protected]: Mezghrani O, Ke X, Bourkaib N, Xu Bh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674636/
Feb 06, 2015 · Herein, a self-microemulsifying drug delivery system (SMEDDS) was developed to improve its solubility and oral bioavailability. AJS-SMEDDS formulation was optimized in terms of drug solubility in the excipients, droplet size, stability, and drug precipitation using a pseudo-ternary diagram.Author: Lan Wu, Yanli Qiao, Lina Wang, Jiahua Guo, Guocheng Wang, Wei He, Lifang Yin, Jinhua Zhao
https://link.springer.com/article/10.1007/s11101-013-9285-5
Apr 06, 2013 · Herein, various pharmaceutical formulations that aim at the bioavailability improvement of these fascinating phytochemicals, i.e., liposomes, phytosomes, self-microemulsifying drug delivery systems, solid dispersions systems, dripping pills, nanosuspensions, floating tablets, and …Author: Eleni Theodosiou, Eleni Theodosiou, Kateřina Purchartová, Haralambos Stamatis, Fragiskos Kolisis, Vl...
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