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http://www.dendritech.com/pamam.html
34 rows · The term "dendrimer" was derived from its tree-like branching structure. The tables below …
https://www.mdpi.com/1420-3049/23/4/938/pdf
branches. As a drug delivery scientist, it is imperative to understand the architecture of dendrimers. 2. Discussion 2.1. Dendrimer-Drug Delivery Strategy PAMAM dendrimers were first reported by Tomalia in 1985 [3,4]. PAMAM dendrimers are one of the most used dendrimers for drug delivery systems [5–7]. The dendrimer architecture has three main
https://www.nature.com/articles/srep23179
Dendrimers have an ideal structure to develop a targeted drug delivery system where drug molecules can be encapsulated in the internal cavities while conjugating a targeting ligand to the free ...
https://www.nrcresearchpress.com/doi/10.1139/cjc-2017-0115
Modeling showed that drug is located in the polymer surface and in the internal cavities. PAMAM nanoparticles are capable of transporting doxorubicin and tamoxifen in vitro. This minireview presents the most recent work performed with the dendrimers demonstrating their usefulness for drug delivery in …
https://www.sigmaaldrich.com/materials-science/material-science-products.html?TablePage=9539880
PAMAM dendrimers consist of alkyl-diamine core and tertiary amine branches. They are available in generations (G) 0 to 10 with 5 different core types and 10 functional surface groups. Most PAMAM dendrimers are supplied as solutions in methanol for improved long-term storage stability.
https://www.europepmc.org/articles/PMC3047462/
PAMAM-RGD conjugates enhance siRNA delivery through a multicellular spheroid model of malignant glioma. Find the latest peer-reviewed research articles and preprints on Coronavirus here. Feedback Complete survey. Sign in or create an account. https ...
https://www.sciencedirect.com/science/article/pii/S092777652030062X
Poly(amidoamine) (PAMAM) dendrimers have been extensively employed for ocular drug delivery due to their innate bioadhesive and enhancing properties of corneal permeation . The bioadhesion of these PAMAM dendrimers can be explained by electrostatic interactions between positively charged dendrimers and negatively charged mucin.
https://en.wikipedia.org/wiki/PAMAM
Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality.PAMAM dendrimers, sometimes referred to by the trade name Starburst, have been extensively studied since their synthesis in 1985, and represent the most well-characterized dendrimer family as well as the first to be commercialized.
http://www.dendritech.com/pamam.html
The term "dendrimer" was derived from its tree-like branching structure. The tables below show the calculated properties* of primary amine surface PAMAM dendrimers by generation, followed by common alternative surfaces. For mixed surfaces or other customized dendrimers, please inquire.
https://www.sigmaaldrich.com/materials-science/material-science-products.html?TablePage=16375655
Applications of dendrimers Applications highlighted in recent literature include drug delivery, gene transfection, catalysis, energy harvesting, photo activity, molecular weight and size determination, rheology modification, and nanoscale science and technology. 1, 2 Dendrimer synthesis
https://www.fasebj.org/doi/abs/10.1096/fj.06-7380com
The blood-brain barrier (BBB) poses great difficulties for gene delivery to the brain. To circumvent the BBB, we investigated a novel brain-targeting gene vector based on the nanoscopic high-branch...
https://chemistry.illinois.edu/system/files/inline-files/Brummond.pdf
APPLICATIONS OF DENDRIMERS TO DRUG DELIVERY Reported by: Catherine A. Brummond March 4, 2004 INTRODUCTION The discovery and creation of new drugs is timely and costly process. It is estimated that every new drug takes 12 to 15 years to develop, at a cost of over $800 million.1,2 A more efficient approach
http://www.japsonline.com/admin/php/uploads/1064_pdf.pdf
dendrimers along with their pharmaceutical application as a potential novel drug delivery carrier. Key words: Dendrimers, PAMAM, monodispersity, nanocarriers, targeted, PEGylation. INTRODUCTION Dendrimers are a new class of polymeric materials. A dendrimer …
https://pubs.acs.org/doi/10.1021/acsami.6b05567
G4 PAMAM dendrimer molecules were modified via covalently conjugating RGDC, RAADyC, and PEG chains on the periphery (Mac-1), by which a nanogel drug carrier with enzyme-sensitivity (NG-1) was constructed through an oxidation reaction by using NaIO4 to initiate the chemical cross-link of the functional groups on the periphery of dendrimers. Mac-1 and NG-1 both had a spherelike shape with …
http://www.pharmtech.com/role-dendrimers-topical-drug-delivery
Dendrimers such as PAMAM have been widely studied, and researchers have found diverse applications for them in biomedical and biological sciences (40–44). In particular, dendrimers have been used as carriers for drug delivery by various routes of administration, including parenteral, oral, topical, transdermal, and ocular.
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