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https://www.tandfonline.com/doi/full/10.1080/03639045.2018.1464022
Apr 11, 2018 · Otic drug delivery technology will likely evolve in the next decade and more efficient or specific treatments for ear disease will arise from the development of less invasive drug delivery methods, safe and highly controlled drug delivery systems, and biotechnology targeting therapies.Author: Xu Liu, Mingshuang Li, Hugh Smyth, Feng Zhang
https://www.researchgate.net/publication/324565100_Otic_Drug_Delivery_Systems_Formulation_Principles_and_Recent_Developments
Otic drug delivery technology will likely evolve in the next decade and more efficient or specific treatments for ear disease will arise from the development of less invasive drug delivery methods, safe and highly controlled drug delivery systems, and biotechnology targeting therapies.
https://www.tandfonline.com/doi/abs/10.1080/03639045.2018.1464022?tab=permissions
(2018). Otic drug delivery systems: formulation principles and recent developments. Drug Development and Industrial Pharmacy: Vol. 44, No. 9, pp. 1395-1408.Author: Xu Liu, Mingshuang Li, Hugh Smyth, Feng Zhang
https://stm.sciencemag.org/content/11/482/eaao0935.full
Mar 06, 2019 · Drug delivery to the inner ear via the vasculature is an attractive noninvasive strategy, yet the blood-labyrinth barrier at the luminal surface of inner ear capillaries restricts entry of most blood-borne compounds into inner ear tissues.Author: Sophie Nyberg, N. Joan Abbott, Xiaorui Shi, Peter S. Steyger, Alain Dabdoub, Alain Dabdoub
https://www.drugs.com/monograph/neomycin-sulfate-eent.html
Neomycin Sulfate eent reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). ... Otic preparations are for ... If ear canal is narrow or edematous and there are concerns that drug delivery might be impeded, 139 consider inserting cotton wick into ear canal and saturating it with the otic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345951/
Feb 20, 2015 · Otic drug delivery – formulation considerations. Drugs that act on the ear in paediatric populations include therapies for otitis externa, otitis media and the removal of ear wax. These medicines are most frequently applied as ear drops and sprays. A small volume is generally used as excess will be lost out of the ear passage.Author: Hannah K. Batchelor, John F. Marriott
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