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https://www.researchgate.net/publication/233658258_Oral_Insulin_Delivery_by_Polymeric_Nanospheres
Oral Insulin Delivery by Polymeric Nanospheres. April 2007; ... it is concluded that using arginine polymeric micelles for the enhancement of oral insulin delivery is a promising approach for the ...
https://www.sciencedirect.com/science/article/pii/S0168365906005797
1. Introduction. Since the parenteral administration is the only route of insulin delivery, alternative routes of administration (oral, nasal, rectal, pulmonary and ocular) have been extensively investigated .Among them, the oral route seems to be the most convenient and physiological because insulin undergoes a first hepatic bypass, thus warranting a primary effect by inhibiting hepatic ...Author: Christiane Damgé, Philippe Maincent, Nathalie Ubrich
https://www.ingentaconnect.com/content/asp/jbn/2007/00000003/00000001/art00008
Apr 01, 2007 · Scanning electron microscope scans showed the formation of smooth, spherical poly-ε-caprolactone nanospheres ensuring the successful formulation of PCL nanospheres encapsulating insulin, thus highlighting poly-caprolactone as a potential …
https://www.sciencedirect.com/science/article/pii/S1359644612001237
Polymers in oral insulin delivery. Over the past few decades, increasing attention has been paid to the use of polymeric nano/microparticles as carriers for oral insulin delivery . A variety of both biodegradable and non-biodegradable polymers have been investigated, but non-biodegradable polymers pose problems of toxicity, difficulty in ...Author: T.A. Sonia, Chandra P. Sharma
https://www.onlinelibrary.wiley.com/doi/full/10.1111/jphp.12852
Nov 28, 2017 · These are all factors that favour a switch to oral delivery of therapeutic peptides such as insulin. 22. Challenges in oral delivery of insulin. The fundamental barrier to the oral delivery of proteins is the gastrointestinal tract (GIT). The GIT functions as an absorptive and protective organ.Author: Ahmed Gedawy, Jorge Martinez, Hani Al‐Salami, Crispin R. Dass
https://www.researchgate.net/publication/272504483_Polymer-based_nanoparticles_for_oral_insulin_delivery_Revisited_approaches
Polymer-based nanoparticles for oral insulin delivery: Revisited approaches ... nanoparticles for oral delivery (e.g. polymeric nanoparticles using synthetic or natural polymers and lipid ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619439/
Oct 24, 2015 · At this juncture, researchers are trying to develop different insulin delivery systems, especially through oral and pulmonary route using nanocarrier based delivery system. This next generation efficient therapy for T1DM may help to improve the quality of life of diabetic patients who routinely employ insulin by the subcutaneous route.Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
https://www.ncbi.nlm.nih.gov/pubmed/11837977
Poly(ethylcyanoacrylate) (PECA) nanospheres have been employed as biodegradable polymeric carriers for oral (po) delivery of insulin. The main goal of this investigation was to screen various absorption enhancers, which were used to protect insulin-loaded PECA, by following their in vivo performance after oral administrations to streptozotocin ...Author: M. A. Radwan, H. Y. Aboul-Enein
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