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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426784/
Chitosan nanoparticles for oral gene delivery. Increasingly, nucleic acids are being applied as drugs, both for vaccination and therapeutic gene expression. Chitosan–DNA nanoparticles may be readily formed by coacervation between the positively charged amine groups on the chitosan and negatively charged phosphate groups on the DNA ...Author: Katherine Bowman, Kam W Leong
https://www.researchgate.net/publication/13095157_Oral_gene_delivery_with_chitosan-DNA_nanoparticles_generates_immunologic_protection_in_a_murine_model_of_peanut_allergy
Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy Article (PDF Available) in Nature Medicine 5(4):387-91 · May 1999 with ...
https://www.researchgate.net/publication/6116863_Chitosan_Nanoparticles_for_Oral_Drug_and_Gene_Delivery
Chitosan Nanoparticles for Oral Drug and Gene Delivery Article · Literature Review (PDF Available) in International Journal of Nanomedicine 1(2):117-28 · February 2006 with 1,147 Reads
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717060/
Jan 01, 2004 · The oral delivery of peptide, protein, vaccine and nucleic acid-based biotechnology products is the greatest challenge facing the drug delivery industry. Oral delivery is most attractive due to easy administration, leading to improved convenience and compliance to patients, thereby reducing the overall healthcare cost. Gene therapy will provide ...Author: Jing Chen, Wu-Li Yang, Ge Li, Ji Qian, Jing-Lun Xue, Shou-Kuan Fu, Da-Ru Lu
https://www.wjgnet.com/2220-3184/full/v6/i3/22.htm
The use of non-viral DNA formulations for oral gene delivery is an area of active research interest. Oral gene delivery via chemical carriers has the potential to treat a number of inherited and acquired diseases. The gastrointestinal (GI) tract’s large surface area provides a massive number of cells that can be potentially targeted.Author: Bhavika J Patel, Nithin K Vignesh, Gonzalo Hortelano
https://www.sciencedirect.com/science/article/pii/S1050464818303255
These results suggest that feed pellets containing chitosan nanoparticles might enable efficient oral delivery of pDNA, a fact that might imply valuable applications in terms of on-farm mass immunization purposes, especially with regard to DNA-based vaccines and small size fish, in which i. m. administration remains unfeasible.Author: M.I. Sáez, A.J. Vizcaíno, F.J. Alarcón, T.F. Martínez
https://www.dovepress.com/chitosan-nanoparticles-for-oral-drug-and-gene-delivery-peer-reviewed-article-IJN
Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptake and promoting gene expression. This review summarizes some of these findings and highlights the potential of chitosan as a component of oral delivery systems. Keywords: chitosan, oral delivery, nanoparticles
https://www.sciencedirect.com/science/article/pii/S0169409X12003535
The nanoparticles with peptidic ligands would be a promising candidate for oral protein delivery. The potential of nanoparticles in drug delivery has remained. Challenges to developing protein formulations for oral delivery are still significant, and the quest to overcome the problem is ongoing.Author: Yeonhee Yun, Yeonhee Yun, Yong Woo Cho, Kinam Park, Kinam Park
https://link.springer.com/chapter/10.1007%2F978-3-662-47862-2_22
An efficient gene delivery system for cellular uptake of DNA is essential for gene therapy. Chitosan has been widely used as a promising non-viral carrier for gene delivery. It is a cationic polymer with free amino groups and can bind to anionic nucleic acids spontaneously.Author: Julide Akbuga, Suna Ozbas-Turan, Ceyda Ekentok
https://fenix.tecnico.ulisboa.pt/downloadFile/395145925983/Resumo%20Tese%20-%20Artigo_FINAL.pdf
Preparation and characterization of chitosan nanoparticles for gene delivery Vasco José Dias Duarte Silva Master degree in Biotechnology Abstract: The possibility of using gene-based therapy for treatment of both genetic and acquired diseases such as infections, degenerative disorders or …File Size: 818KB
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