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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Oral drug delivery (ODD) is the most preferred and convenient route of drug administration due to high patient compliance, cost-effectiveness, least sterility constraints, flexibility in the design of dosage form and ease of production.
http://ijpsr.com/bft-article/liver-specific-drug-targeting-strategies-a-review/?view=fulltext
ABSTRACT: Drug delivery to liver is one of the most challenging research areas in pharmaceutical sciences. The some physiological barrier such as opsonization, mechanical entrapment by pulmonary vascular bed, uptake by RES represents an insurmountable obstacle for a large number of proteins and drugs, including antibiotics, antineoplastic agents and antiviral agents to target liver disorders.
https://www.pharmacytimes.com/publications/issue/2016/august2016/delivery-methods-the-patch-versus-the-oral-route
Oral administration remains the most commonly used route for medication. An oral medication generally becomes active when it passes from the gastrointestinal tract and the liver into the blood.1 Most newly approved medications are developed in oral forms to improve patient access and adherence, especially for oncology-related medications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780723/
The liver-specific drug delivery can be rationalized with the mechanism of lipid metabolism.38,39 In the reported mechanism, the emulsions can be metabolized via the comparable metabolism pathway of chylomicron or removed from the plasma by the cells of the mononuclear phagocyte system when the emulsions are recognized as foreign materials.38 If the LCNPs are recognized as a foreign material, …Author: Dong Ryeol Lee, Ji Su Park, Il Hak Bae, Yan Lee, B Moon Kim
https://sunrisehouse.com/cause-effect/path-drugs-take-body/
This takes place mostly in the body’s largest internal organ, the liver. (Note: While the liver is the primary site for drug metabolism, other organs such as the kidneys, GI tract, and lungs may also perform metabolic functions.) 13,16 During this phase, proteins called enzymes break down the drug …
https://www.slideshare.net/sagarsavale1/oral-drug-delivery-system-odds
May 29, 2016 · Sustain Release Drug Delivery System Definition: “Drug Delivery system that are designed to achieve prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose” is known as Sustained drug Delivery system. The basic goal of therapy is to achieve steady state blood level that is therapeutically effective and non …
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Nanocarriers for drug delivery. Nanomedicine is a rapidly developing area that is revolutionizing cancer diagnosis and therapy. Nanoparticles …Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
http://globalresearchonline.net/journalcontents/v21-1/13.pdf
patient specially having difficulty in swallowing oral medicine 1. Drug delivery can be stopped by removing the dosage form and drug absorption can be easily interrupted in cases of accidental overdose or suicide attempts. Drug which traditionally is only given parentally may be administered rectally. These advantages for rectalFile Size: 359KB
https://en.wikipedia.org/wiki/First_pass_effect
It is carried through the portal vein into the liver before it reaches the rest of the body. The liver metabolizes many drugs, sometimes to such an extent that only a small amount of active drug emerges from the liver to the rest of the circulatory system. This first pass through the liver thus may greatly reduce the bioavailability of the drug.
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