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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Oral Drug Delivery. Oral drug delivery (ODD) is the most preferred and convenient route of drug administration due to high patient compliance, cost-effectiveness, least sterility constraints, flexibility in the design of dosage form and ease of production.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410172/
Feb 13, 2019 · Salcaprozate sodium (SNAC) and sodium caprate (C 10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules.Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action.Author: Caroline Twarog, Sarinj Fattah, Joanne Heade, Sam Maher, Elias Fattal, David J. Brayden
https://medicalxpress.com/news/2020-04-toss-syringe-oral-delivery-drugs.html
1 day ago · Oral delivery of biologics is a challenge that many engineers and chemists have tried to address, and one that becomes more urgent as modalities trend toward peptide, antibody, and …
https://www.ncbi.nlm.nih.gov/pubmed/31686002
The oral delivery of bioactive peptides and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecules. Here we show that anionic nanoparticles induce tight junction relaxation, increasing intestinal permeability and enabling the oral delivery of proteins.Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead
https://otd.harvard.edu/explore-innovation/technologies/oral-delivery-of-biologics
As oral delivery is associated with high compliance and low cost, one potential solution would be to deliver biologics orally (while simultaneously preserving their systemic effects). The Mitragotri laboratory at Harvard has developed a novel platform technology …
http://www.pharmtech.com/oral-delivery-biologic-apis-challenge-continues
Mar 02, 2017 · Mopic/shutterstock.com Oral delivery of drugs is the preferred route of administration by both patients and manufacturers. Ease and convenience are the greatest requirements for patients, which leads to higher medicine adherence. Production costs for oral dosage forms also tend to be lower than for other options and offer the greatest versatility with respect to optimization of drug delivery.
https://www.sciencedirect.com/book/9781907568473/oral-delivery-of-insulin
Abstract. One of the greater challenges faced by oral delivery of insulin is the reduced bioavailability. Among the different types of carrier-based delivery systems currently being pursued for oral insulin delivery, biodegradable polymeric nanoparticles have received considerable attention due to their versatility and wide range of properties.
https://www.nature.com/articles/s41467-019-13727-9
Dec 19, 2019 · Oral microbiota delivery is an approach to treat and prevent disease but suffers from low retention and bioavailability. Here the authors report on a lipid coating to protect against environmental ...Author: Zhenping Cao, Xinyue Wang, Yan Pang, Shanshan Cheng, Jinyao Liu
https://www.medscape.com/viewarticle/581891
Oct 18, 2019 · Oral Vaccines. Vaccination is an efficient and cost-effective form of preventing infectious diseases. However, most currently available vaccines are delivered by injection, which makes mass ...
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