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https://otd.harvard.edu/explore-innovation/technologies/oral-delivery-of-biologics
Oral delivery of biologics Biologics are used to treat a variety of chronic diseases including diabetes and arthritis. Not surprisingly, they command a large share of the therapeutics market.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201901935
Jun 20, 2019 · Oral Delivery of Biologics for Precision Medicine. Matilde Durán‐Lobato. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain. IDIS Research Institute, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.Author: Matilde Durán‐Lobato, Zhigao Niu, Zhigao Niu, María José Alonso
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732838/
Oral delivery of biologics using drug-device combinations Ester Caffarel-Salvador , 1, 2, * Alex Abramson , 2, * Robert Langer , 1, 2, § and Giovanni Traverso 2, 3, § Ester Caffarel-SalvadorAuthor: Ester Caffarel-Salvador, Alex Abramson, Robert Langer, Giovanni Traverso, Giovanni Traverso
https://www.biopharma-reporter.com/Article/2019/03/18/Oral-delivery-of-biologics
Mar 18, 2019 · Drug delivery of biologics takes a sharp turn, as the development of pills that can replace injections and increase drug accessibility moves forward. Both Rani Therapeutics and researchers at Massachusetts Institute of Technology (MIT) have separately developed orally administered capsules, the RaniPill and the self-orienting micro-applicator (SOMA), to replace the injections often required for …
https://www.pharmaceutical-journal.com/research/review-article/recent-advances-in-the-oral-delivery-of-biologics/20207374.fullarticle
Coupled with recent advances in materials, research into oral delivery of biologics is increasingly producing more clinically relevant drug-delivery technologies, with the potential to make oral administration of biologics a viable option.
https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1504017
Jul 17, 2018 · Introduction: Research into oral delivery of biologics has a long and rich history but has not produced technologies used in the clinic. The area has evolved in terms of strategies to promote oral biologics delivery from early chemical absorption enhancers to nanomedicine to devices.Author: Driton Vllasaliu, Maria Thanou, Snjezana Stolnik, Robyn Fowler
https://www.nature.com/articles/nrd.2018.183
Nov 30, 2018 · Given the rise of peptides and proteins in the pharmaceutical landscape, tremendous research and development interest exists in developing less-invasive or non-invasive routes for the systemic delivery of biologics, including subcutaneous, transdermal, oral, inhalation…Author: Aaron C. Anselmo, Yatin Gokarn, Samir Mitragotri
https://www.ncbi.nlm.nih.gov/pubmed/30033780
Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery. Vllasaliu D(1), Thanou M(1), Stolnik S(2), Fowler R(3). Author information: (1)a School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine , King's College London , London , …Author: Driton Vllasaliu, Maria Thanou, Snjezana Stolnik, Robyn Fowler
http://www.pharmtech.com/oral-delivery-biologic-apis-challenge-continues
Mar 02, 2017 · The greatest challenge to the oral delivery of biologic APIs is absorption across the GI tract, according to Ronak Savla, scientific affairs manager, Catalent Pharma Solutions. Most oral drugs are absorbed in the small intestine, which has the highest permeability compared to the large intestine and stomach.
http://www.pmlive.com/pharma_intelligence/oral_biologics_delivery_still_elusive_908436
In fact, diabetes is thought to be the single largest area for oral delivery of biologics, with a number of groups working on oral insulin as well as analogues of glucagon - like peptide-1 (GLP-1), a hormone that works independently of insulin to stimulate glucose release. Now,...
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