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https://www.pharmatutor.org/articles/oral-controlled-release-drug-delivery-system-review
Drugs existing largely in ionized form are poor candidate for oral controlled release drug delivery system because absorption rate of ionized drug is 3-4 times less than that of unionized form. The pKa range for acidic drug whose ionization is pH sensitive is around 3.0-7.5 and for basic drug whose ionization is pH sensitive is around 7.0-11.0 are ideal for optimum positive absorption.Author: M Gahlyan, S Jain
http://www.ijpacr.com/files/06-07-15/204072015.pdf
Oral controlled release drug delivery is a system that provides continuous oral delivery of drugs at predictable and reproducible kinetics for a predetermined period throughout the course of GI transit and also the system that target the delivery of a drug to a specific region within the GI tract for either a local or systemic action (Vora et al., 1996). Classification of Oral Controlled Release System
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225522/
Sep 15, 2011 · A novel oral drug delivery system for the controlled release of liquid drugs, drug solutions, and semisolid drug preparations is presented that is utilizing the constant vapor pressure of liquefied gas. The system is equipped with a capillary as an element ...Author: Dorota Haznar-Garbacz, Dorota Haznar-Garbacz, Grzegorz Garbacz, Friederike Eisenächer, Sandra Klein,...
https://www.slideshare.net/bhupendrakumaryadav/controlled-release-oral-drug-delivery-system
Dec 06, 2014 · Controlled Release Oral Drug Delivery System. Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
INTRODUCTION: Controlled drug delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrations, optimal use of the drug in question, and increased patient compliance. higher cost of controlled-release systems compared with …
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