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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
This review will provide an overview on various conventional and novel ophthalmic drug delivery systems developed to deliver drug to diseased ocular tissues for the treatment of ocular diseases. CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMSAuthor: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/ophthalmic-drug-delivery
Ophthalmic drug delivery systems are essential to improve duration, targeting and compliance. For chronic diseases such as glaucoma, macular degeneration and diabetic retinopathy, administration routes can include oral, parenteral, topical, sub-conjunctival, intracameral, intravitreal, sub-Tenon's, intrascleral, and subretinal.
https://www.researchgate.net/publication/272761267_OPHTHALMIC_DRUG_DELIVERY_SYSTEM_AN_OVERVIEW
Ophthalmic CDDS (controlled drug delivery system) have been mainly prepared as gels, ointments, liposomes, micro and Nanoparticles, micro spheres and ocular minitablets (MT) or films or inserts ...
https://www.allfordrugs.com/ocular-drug-delivery-systems-an-overview/
The development of an ophthalmic drug delivery system based on cyclodextrins is relatively recent, occurring in the Patel GM, et al.: Advances and challenges in ocular drug delivery system early 1990s. Cyclodextrins were introduced in ocular drug formulations initially with the aim of increasing the solubility of lipophilic drugs in solution.
https://www.academia.edu/37617859/OPHTHALMIC_DRUG_DELIVERY_SYSTEM_AN_OVERVIEW
Ideal ophthalmic drug delivery must be able to sustain the drug release and to remain in the vicinity of front of the eye for prolong period of time. Ocular drug delivery is one of the interesting and challenging endeavors facing the pharmaceutical
https://www.mdpi.com/1999-4923/10/1/10
Abstract. The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on...Author: Marion Dubald, Sandrine Bourgeois, Véronique Andrieu, Hatem Fessi
http://ijpsr.com/bft-article/ocular-drug-delivery-system-an-overview/?view=fulltext
In ocular drug delivery system there are two types of barriers static and dynamic barrier. Static barriers consist of different segment of eye such as cornea, sclera, retina and blood- retinal barriers. In other way dynamic barriers consists choroidal and conjunctival blood flow, lymphatic clearance,...
https://innovareacademics.in/journal/ijpps/Vol2Suppl4/875.pdf
delivery systems often result in poor bioavailability and therapeutic response because high tear fluids turn over and dynamics cause rapid elimination of the drug from the eyes. So, to overcome bioavailability problems, ophthalmic in situ gels were developed.
https://www.researchgate.net/publication/270964184_Ocular_drug_delivery_systems_An_overview
conventional and novel ophthalmic drug delivery systems developed to deliver drug to diseased ocular tissues for the treatment of ocular diseases. Patel et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications. ... been published and will not be discussed here. 76 –78 Csaky emphasized that many drug formulations are not optimized for ophthalmic drug delivery, and need to be adapted for use in an existing or developing drug delivery system ...Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
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