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https://www.sciencedirect.com/science/article/pii/S0025556409001333
On optimal delivery of combination therapy for tumors. ... we focus on the problem of optimizing the delivery for the relevant case of a combined therapy of a vessel disrupting and a cell cytotoxic agent. Mathematically, the challenge lies in the fact that this is now a multi-control problem and in this case leads to a more complex structure of ...Author: Alberto d’Onofrio, Urszula Ledzewicz, Helmut Maurer, Heinz Schättler
https://www.researchgate.net/publication/26766374_On_optimal_delivery_of_combination_therapy_for_tumors
For instance, [13] explored the role of mathematical modeling on the optimal delivery of a combination therapy for tumors and to improve on the delivery of anti-tumor drugs. ...
https://www.sciencedirect.com/science/article/abs/pii/S0025556409001333
A mathematical model for the scheduling of angiogenic inhibitors in combination with a chemotherapeutic agent is formulated. Conditions are given that allow tumor eradication under constant infusion therapies. Then the optimal scheduling of a vessel disruptive agent in combination with a cytotoxic drug is considered as an optimal control problem.Author: Alberto d’Onofrio, Urszula Ledzewicz, Helmut Maurer, Heinz Schättler
https://moh-it.pure.elsevier.com/en/publications/on-optimal-delivery-of-combination-therapy-for-tumors
T1 - On optimal delivery of combination therapy for tumors. AU - d'Onofrio, Alberto. AU - Ledzewicz, Urszula. AU - Maurer, Helmut. AU - Schättler, Heinz. PY - 2009/11. Y1 - 2009/11. N2 - A mathematical model for the scheduling of angiogenic inhibitors in combination with a …Author: Alberto d’Onofrio, Urszula Ledzewicz, Helmut Maurer, Heinz Schättler
https://www.deepdyve.com/lp/elsevier/on-optimal-delivery-of-combination-therapy-for-tumors-CXZy3QPXem
Nov 01, 2009 · Read "On optimal delivery of combination therapy for tumors, Mathematical Biosciences" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.ncbi.nlm.nih.gov/pubmed/30308300
Targeted codelivery of doxorubicin and IL-36γ expression plasmid for an optimal chemo-gene combination therapy against cancer lung metastasis. ... Gene transfection in both lungs and s.c. tumors was significantly higher with our polymer compared to PEI. ... POEG-st-Pmor may represent a simple and effective delivery system for an optimal chemo ...Author: Yichao Chen, Jingjing Sun, Yixian Huang, Yanhua Liu, Lei Liang, Da Yang, Binfeng Lu, Song Li
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900555/
To study whether combinatorial therapies delivered at optimal immunotherapy timing can still impact tumors with lower mutational burden we aimed to develop a model of radiation therapy in mice bearing spontaneous tumors. These tumors would be anticipated to …Author: Kristina H. Young, Jason R. Baird, Talicia Savage, Benjamin Cottam, David Friedman, Shelly Bambina, ...
https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30426-X
This can be further amplified by the addition of CPB agents, which serve to counteract the immune inhibitory environment undermining optimal CAR T cell efficacy. Herein, we review preclinical and clinical combination therapy with CAR T cells and CPB agents, with a focus on solid tumor malignancies.Author: Rachel Grosser, Leonid Cherkassky, Navin Chintala, Prasad S. Adusumilli
https://ro-journal.biomedcentral.com/articles/10.1186/s13014-017-0841-9
Jun 19, 2017 · The incidence of brain tumors in the elderly population has increased over the last few decades. Current treatment includes surgery, radiotherapy and chemotherapy, but the optimal management of older patients with brain tumors remains a matter of debate, since aggressive radiation treatments in this population may be associated with high risks of neurological toxicity and …Author: Giuseppe Minniti, Andrea Riccardo Filippi, Mattia Falchetto Osti, Umberto Ricardi
https://www.tandfonline.com/doi/pdf/10.1080/15548627.2016.1162930
delivery to tumors and into lysosomes, and whether this would ... as well as new approaches for combination therapy involving DOXorotherchemotherapeutics(Fig.1). Results Liposome characterization ... Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved ...
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