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https://www.researchgate.net/publication/26700970_Oligoarginine-PEG-lipid_particles_for_gene_delivery_Expert_Opin_Drug_Deliv_61065-1077
Oligoarginine-PEG-lipid particles for gene delivery. Expert Opin Drug Deliv 6:1065-1077. Cell-penetrating peptides (CPPs) are small peptides that can facilitate the uptake of macromolecular drugs, such as proteins or nucleic acids, into mammalian cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
Ionizable lipids are an advanced delivery platform of gene therapy that can self-assemble into nanoparticles when mixed with polyanionic nucleic acids. Ionizable cationic lipids with modulated pKa values increase nucleic acid payload and enhance the therapeutic efficacy of gene therapy.Author: Yi Zhao, Leaf Huang
https://pubs.acs.org/doi/10.1021/bc050164a
Oligoarginine-PEG-lipid particles for gene delivery. Expert Opinion on Drug Delivery 2009, 6 (10) , 1065-1077. DOI: 10.1517/17425240903156366. Santanu Bhattacharya, Avinash Bajaj. Advances in gene delivery through molecular design of cationic lipids.
https://www.sciencedirect.com/science/article/pii/S014296121500770X
Nuclear delivery induced by cationic nanoparticles, such as oligoarginine peptide (Arg8) nanoparticles, may be an attractive option to improve transgene expression and delivery of genes, including DNA or siRNA, into the nuclei of target cells [16], [17], [18].Author: Ji Young Yoon, Keum-Jin Yang, Da Eun Kim, Kyu-Yup Lee, Shi-Nae Park, Dong-Kee Kim, Jong-Duk Kim
https://www.ingentaconnect.com/content/asp/jnn/2008/00000008/00000005/art00013
Differences in transfection efficiency of the complexes may be explained by a large fibrous nanostructure inhibiting the cellular internalization of complexes or the release of DNA from macropinosomes into cytoplasm. Arg10-PEG-lipid/DNA complexes formed a favorable nanostructure for gene delivery, depending on the N/P ratio in water.
https://www.sciencedirect.com/science/article/pii/S0168365908001983
These results indicated that the in vitro system for evaluating oligoarginine-mediated gene delivery did not reflect the optimal condition of in vivo gene delivery. To confirm gene expression in the tumor, we observed the gene expression of the plasmid pEGFP-C1 with (Arg)n-B-PD(0.3) using fluorescence microscopy ( Fig. 4 ).Author: Takashi Fujita, Masahiko Furuhata, Yoshiyuki Hattori, Hiroko Kawakami, Kazunori Toma, Yoshie Maitani
https://www.researchgate.net/publication/5283085_Decaarginine-PEG-Artificial_LipidDNA_Complex_for_Gene_Delivery_Nanostructure_and_Transfection_Efficiency
Decaarginine-conjugated lipid (Arg10-PEG-lipid) was synthesized and the effects of Arg10-PEG-lipid concentration at a fixed DNA concentration on transfection efficiency and the structure of the complexes were studied below...
https://www.nature.com/articles/3301308
Nov 06, 2000 · the structure of ‘stabilized plasmid-lipid particles’ (splp) and their properties as systemic gene therapy vectors has been investigated. we show that splp can be visualized employing cryo-electron microscopy to be homogeneous particles of diameter 72 ± 5 nm consisting of a lipid bilayer surrounding a core of plasmid dna.Author: P. Tam, M. Monck, D. Lee, O. Ludkovski, E. C. Leng, K. Clow, H. Stark, P. Scherrer, R. W. Graham, P....
https://pubs.acs.org/doi/10.1021/bc025567e
These compounds were designed to follow the biodistribution of synthetic DNA for gene delivery by nuclear magnetic resonance imaging. The lipid MCO-I-68 was synthesized, and chelate complexes with gadolinium were formed and characterized in terms of physicochemical and DNA binding properties.Author: Francoise Leclercq, Mirit Cohen-Ohana, Nathalie Mignet, Andrea Sbarbati, Jean Herscovici, Daniel Sch...
https://en.wikipedia.org/wiki/Gene_delivery
Chemical based methods of gene delivery can use natural or synthetic compounds to form particles that facilitate the transfer of genes into cells. These synthetic vectors have the ability to electrostatically bind DNA or RNA and compact the genetic information to accommodate larger genetic transfers.
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