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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
To overcome the ocular drug delivery barriers and improve ocular bioavailability, various conventional and novel drug delivery systems have been developed such as emulsion, ointments, suspensions, aqueous gels, nanomicelles, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles, and in situ ...Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.healio.com/ophthalmology/cornea-external-disease/news/print/ocular-surgery-news/%7Bd69fee03-15c5-4fbd-a090-4f8a5b294c17%7D/understanding-topical-ophthalmic-drug-delivery-how-much-gets-in
Ocular Surgery News In understanding how much of an artificial tear or a prescription eye drop actually reaches its target tissue, it is helpful to appreciate the significant obstacles to drug ...
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
A successful design of a drug delivery system, therefore, requires an integrated knowledge of the drug molecule and the constraints offered by the ocular route of administration [3].
https://www.sciencedirect.com/topics/medicine-and-dentistry/ocular-drug
Given the poor ocular drug bioavailability by topical route, effective drug delivery to the anterior and, especially, posterior segment of the eye is challenging. The elimination from lachrymal fluid and the corneal barrier after topical administration are the main problems.
https://www.researchgate.net/profile/Sudip_Das4/publication/279418971_Microparticles_and_Nanoparticles_in_Ocular_Drug_Delivery/links/5b8cd0e3299bf1d5a73a0ba4/Microparticles-and-Nanoparticles-in-Ocular-Drug-Delivery.pdf
II. PARTICULATE SYSTEMS IN OCULAR DRUG DELIVERY A. Topical Systems The isolation of the vitreous caused by the blood-retinal and blood-aqueous barriers creates difficulties for effective drug ...
https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems
Sep 17, 2012 · ocular drug delivery systems 1. INTRODUCTION Ocular administration of drug isprimarily associated with the need totreat ophthalmic diseases. Eye is the most easily accessible site fortopical administration of a medication. Ideal ophthalmic drug delivery mustbe able to sustain the drug release andto remain in the vicinity of front of theeye for prolong period of time.
https://www.allfordrugs.com/ocular-drug-delivery-systems-an-overview/
Routes of ocular drug delivery There are several possible routes of drug delivery into the ocular tissues (Fig. 3). The selection of the route of administration depends primarily on the target tissue. Traditionally topical ocular and subconjunctival administrations are used for anterior targets and intravitreal administration for posterior targets.
https://www.slideshare.net/sagarsavale1/ocular-drug-delivery-system-odds-62796410
Jun 07, 2016 · “The Novel approach of drug delivery system in which drug can Instilled on the cull de sac cavity of eye is known has Ocular drug delivery system”. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
https://www.sciencedirect.com/science/article/pii/S1359644618303994
Ocular drug delivery is a field in which regular ADME tools are not useful. • Pharmacokinetics based dosing aid for ocular drug delivery is presented. • User-friendly dosing aid guides early stage design of delivery systems. • Guidance for the delivery route, dosing and formulation design is presented.Author: Astrid Subrizi, Astrid Subrizi, Eva M. del Amo, Viktor Korzhikov-Vlakh, Tatiana Tennikova, Marika Ru...
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