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https://www.ncbi.nlm.nih.gov/pubmed/17716187
Nanocarriers, such as nanoparticles, liposomes and dendrimers, are used to enhance ocular drug delivery. Easily administered as eye drops, these systems provide a prolonged residence time at the ocular surface after instillation, thus avoiding the clearance mechanisms of the eye.Author: Jo Vandervoort, Annick Ludwig
https://www.researchgate.net/publication/6124221_Ocular_drug_delivery_Nanomedicine_applications
Nanocarriers, such as nanoparticles, liposomes and dendrimers, are used to enhance ocular drug delivery. Easily administered as eye drops, these systems provide a prolonged residence time at the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Local drug delivery or drug targeting results in increased local drug concentrations and provides strategies for more specific therapy. Nanoparticles have specific particles as tools to enable these strategies. These include benefits such as their small size which allows penetration of cell membranes,...Author: Wim H De Jong, Paul Ja Borm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617524/
Even though eye drops are the most conventional formulation for ocular drug delivery, they typically provide low bioavailability (less than 5%) owing to poor pre-corneal retention and penetration. The factors affecting pre-corneal retention include rapid tear turnover, blinking, and solution drainage, which result in the loss of drug after topical administration.
https://www.sciencedirect.com/science/article/pii/S1359644618304355
Nanomedicine offers many advantages over conventional ophthalmic medications for effective ocular drug delivery because nanomedicine can increase the therapeutic index by overcoming ocular barriers, improving drug-release profiles and reducing potential drug toxicity.Author: Tuo Meng, Vineet Kulkarni, Russell Simmers, Vikram Brar, Qingguo Xu
https://pharmacy.vcu.edu/pharmaceutics/research/ocular-drug-delivery/
Nanomedicine and Ocular Drug Delivery Nanotherapeutics Website The unifying theme of Dr. Xu’s research program is the synthesis and characterization of new biomaterials engineered to control the delivery of therapeutics for site-specific, controlled release of therapeutics to safely treat blindness and cancer, two critically important global health issues.
https://www.researchgate.net/publication/333122568_Therapeutic_implications_of_nanomedicine_for_ocular_drug_delivery
Ocular nanomedicine poses a promising therapeutic potential and offers many advantages over conventional ophthalmic medications for effective ocular drug delivery; because nanomedicine …
https://www.sciencedirect.com/science/article/pii/B9780128136676000048
Topical administration is a highly desirable ocular drug delivery method, due to its noninvasive and patient-friendly nature. Consequently, more than 90% of ophthalmic formulations currently on the market are topical eye drops (Abdelkader and Alany, 2012).Author: Priyanka Agarwal, Di Huang, Sachin S. Thakur, Ilva D. Rupenthal
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0392-8
Sep 19, 2018 · By using various types of nanoparticles for the delivery of the accurate amount of drug to the affected cells such as the cancer/tumour cells, without disturbing the physiology of the normal cells, the application of nanomedicine and nano-drug delivery system is certainly the trend that will remain to be the future arena of research and development for decades to come.Author: Jayanta Kumar Patra, Gitishree Das, Leonardo Fernandes Fraceto, Leonardo Fernandes Fraceto, Estefani...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990589/
Aug 18, 2016 · Abstract Rapid advances in nanomedicine have significantly changed many aspects of nanoparticle application to the eye including areas of diagnosis, imaging and more importantly drug delivery. The nanoparticle-based drug delivery systems has provided a solution to various drug solubility-related problems in ophthalmology treatment.Author: Shuo You, Jing Luo, Hans E. Grossniklaus, Ma-Ling Gou, Ke Meng, Qing Zhang
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