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https://www.tandfonline.com/doi/abs/10.1586/eop.11.66
(2011). Ocular drug delivery for bioactive proteins. Expert Review of Ophthalmology: Vol. 6, No. 6, pp. 657-667.Author: Tsutomu Yasukawa, Yasuhiko Tabata, Hideya Kimura, Yuichiro Ogura
https://www.researchgate.net/profile/Tsutomu_Yasukawa2/publication/262794673_Ocular_drug_delivery_of_bioactive_proteins/links/54b9a7090cf2d11571a4b6c6.pdf?inViewer=true&pdfJsDownload=true&disableCoverPage=true&origin=publication_detail
sclerosis, and other systemic diseases. However, intraocular delivery of bioactive proteins remains a critical problem to be overcome. The cornea, sclera, tear turnover, frontward current of
https://www.researchgate.net/publication/262794673_Ocular_drug_delivery_of_bioactive_proteins
Ocular dru g delivery fo r bioactive prote ins An acidic gelati n hydrogel sheet is prepared, cut into a 1 × 2-mm rect an gle sh ape, and impre gnat ed wit h the solut ion conta in ing
https://link.springer.com/chapter/10.1007/978-3-319-47691-9_8
Nov 18, 2016 · Additionally, the delivery of a peptide or protein-based drugs is particularly challenging due to the issues of protein instability. This chapter discusses the development of proteins and peptides for ocular delivery with an emphasis on their specific considerations and challenges, and a role of specific proteins such as alpha crystallins and thymosin β4 in ocular drug delivery.Author: Lunawati Bennett
https://www.sciencedirect.com/science/article/pii/B9780123849359100057
An ocular insert for the delivery of insulin using Gelform® as a drug carrier to deliver insulin with the aid of Brij-78 as an absorption enhancer has also been demonstrated [19]. The conjunctival cul-de-sac has also been targeted as a potential route for insulin delivery [20]. Permeation enhancers such as …Author: Suresh P. Vyas, Rishi Paliwal, Shivani Rai Paliwal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995646/
Feb 15, 2018 · Ocular drug delivery nanowafer: (A) Schematic of nanowafer instilled on the cornea. (B) Diffusion of drug molecules into the corneal tissue. (C) Nanowafer on a fingertip. (D) AFM image of a nanowafer demonstrating an array of 500 nm diameter nanoreservoirs. (E) Fluorescence micrograph of a nanowafer filled with doxycycline (scale bar 5 μm).Author: Abhirup Mandal, Dhananjay Pal, Vibhuti Agrahari, Hoang My Trinh, Mary Joseph, Ashim K. Mitra
https://www.researchgate.net/publication/322468712_Ocular_delivery_of_proteins_and_peptides_Challenges_and_novel_formulation_approaches
Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · The most commonly applicable influx transporters for ocular drug delivery are amino acid and peptide transporters. These proteins may have a putative role in ocular drug delivery along with their physiological role of transporting various amino acids and nutrients into ocular tissues.Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.sciencedirect.com/science/article/pii/B9780128097175000129
Bioadhesive drug delivery systems can be delivered through various routes like oral, nasal, ocular, and vaginal. The main components of bioadhesive drug delivery systems are bioadhesive polymers, which may be natural or synthetic in nature.Author: Lalit Kumar, Shivani Verma, Bhuvaneshwar Vaidya, Vivek Gupta
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