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https://www.sciencedirect.com/science/article/pii/0169409X9500012V
Ocular drug delivery conventional ocular formulations. Abstract. Within the last few decades, in response to the advent of potent and versatile therapeutic agents, the diversity of conventional ophthalmic formulations has gradually evolved, extending well beyond simple solutions, and now includes a variety of types of drug administration.Author: John C. Lang
https://www.sciencedirect.com/science/article/abs/pii/0169409X9500012V
Within the last few decades, in response to the advent of potent and versatile therapeutic agents, the diversity of conventional ophthalmic formulations has gradually evolved, extending well beyond simple solutions, and now includes a variety of types of drug administration.Author: John C. Lang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS. Topical drop instillation into the lower precorneal pocket is a patient compliant and widely recommended route of drug administration. However, most of the topically administered dose is lost due to reflux blinking and only 20% (−7 μL) of instilled dose is retained in the precorneal pocket . Concentration of drug available in the precorneal …Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.arvo.org/globalassets/annual-meeting/program/education-courses/2020-agenda---ocular-drug-delivery.pdf
Ocular drug delivery: Fundamentals, challenges, and technologies Organizers Ash Jayagopal, PhD, Kodiak Sciences Inc. and Uday Kompella, PhD, University of Colorado, Anschutz Medical Campus Description Ocular drug delivery is an evolving field featuring cutting-edge advances in devices, formulations, and paradigms for design and characterization.
https://journals.sagepub.com/doi/pdf/10.1177/0192623307310955
of new technologies in ocular drug delivery and new drug can-didates, including biologics, to treat these challenging diseases in the anterior and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delive ry (Figure 1). Current routes
https://innovareacademics.in/journal/ijpps/Vol2Issue4/434.pdf
CONVENTIONAL OCULAR DRUG DELIVERY SYSTEMS Liquid Viscous Solutions 1. Viscosity improver In order to prolong precorneal residence time and to improve bioavailability, attempts were made to increase the viscosity of the formulation. The viscosity enhancers used were hydrophilic
https://www.pharmatutor.org/articles/review-on-ocular-drug-delivery
Therefore many ophthalmic drug delivery systems are available. These are classified as conventional and non-conventional (newer) drug delivery systems. Most commonly available ophthalmic preparations are eye drops and ointments about 70% of the eye dosage formulations in market.
https://www.ncbi.nlm.nih.gov/pubmed/25590022
Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also, it includes development of conventional topical formulations such as suspensions, emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.researchgate.net/publication/311451337_Formulation_Approaches_for_Ocular_Drug_Delivery
Ocular drug delivery systems based on polymers offer the considerable advantages of improving drug availability and decreasing side effects compared to conventional therapeutic methods.
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