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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for longer duration in target tissues.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · The most commonly applicable influx transporters for ocular drug delivery are amino acid and peptide transporters. These proteins may have a putative role in ocular drug delivery along with their physiological role of transporting various amino acids and nutrients into ocular tissues.Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://pharm.ucsf.edu/desai/research/ocular-drug-delivery
Ocular Drug Delivery Ocular diseases affect one of the most indispensable senses and cause significant impacts to quality of life, particularly in the elderly. The delicate structures of the eye require particular care when developing novel therapies.
https://staging.controlledreleasesociety.org/focus-groups/ocular-delivery-ocd
Ocular Delivery (OcD) The use of drug delivery systems to offer increased safety and utility of ocular therapeutics is a rapidly evolving and ever growing field. Controlled release systems have been employed to both reformulate existing drugs and design new drugs to meet the high potential for commercial interest and patient benefit.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781321/
Sep 06, 2019 · The ascending of new delivery systems for ocular targeting is a current focus, mainly because of the capacity to extend the normal time during which the drug exerts its therapeutic effect and, so, supplying the patients with a product which gives them fewer side effects, fewer number of applications and even more effective outcomes to their pathologies, surpassing the traditionally-used …Author: Eliana B. Souto, João Dias-Ferreira, Ana López-Machado, Miren Ettcheto, Amanda Cano, Antonio Camins ...
https://www.ncbi.nlm.nih.gov/pubmed/25590022
Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic drug levels are not maintained for longer duration in target tissues.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.sciencedirect.com/science/article/pii/S1359644618303994
Ocular drug delivery is a complex field in which multiple factors determine the drug concentrations and, thus, efficacy at the target site. Furthermore, drug loading and required release rates are strongly dependent on the local site of drug administration and location of the target tissue.Author: Astrid Subrizi, Astrid Subrizi, Eva M. del Amo, Viktor Korzhikov-Vlakh, Tatiana Tennikova, Marika Ru...
https://www.sciencedirect.com/science/article/pii/S0169409X18300085
While there are several examples of nanoparticle-mediated ocular delivery systems for small-molecules at preclinical and clinical stages, there only few for proteins …Author: Abhirup Mandal, Dhananjay Pal, Vibhuti Agrahari, Hoang My Trinh, Mary Joseph, Ashim K. Mitra
https://www.sciencedirect.com/science/article/pii/S0168365918303717
Indeed, ocular delivery, in particular to the posterior eye segment, is challenging due to the peculiar structure of this organ and the presence of static, dynamic …Author: S. Pescina, C. Ostacolo, I.M. Gomez-Monterrey, M. Sala, A. Bertamino, F. Sonvico, C. Padula, P. Sant...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171267/
Apr 08, 2011 · Both degradable and nondegradable polymers have been studied for injectable systems for ocular delivery. 70 Non-degradable polymers such as poly(ethylene-co-vinyl acetate) exhibit long term, constant rates of delivery for a number of drugs; 71 however, their disadvantage is the continued presence of a foreign body with a resulting immune response. Degradable polymers such as …Author: Erin Baker Lavik, M. H. Kuehn, Y. H. Kwon
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