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https://www.sciencedirect.com/science/article/pii/0169409X95000105
Ocular absorption and pharmacokinetics have been discussed comprehensively in many earlier chapters and reviews [2,3,8,22-25]. This review summarizes the main features of drug absorption after ocular topical administration and the most recent literature on ocular drug absorption high- lighting some interesting new developments. 2.Author: Kristiina Järvinen, Tomi Järvinen, Arto Urtti, Arto Urtti
https://www.sciencedirect.com/science/article/abs/pii/0169409X95000105
Most ocular diseases are treated with topical application of eyedrops. After instillation of an eyedrop, typically less than 5% of the applied drug penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is absorbed and enters the systemic circulation.Author: Kristiina Järvinen, Tomi Järvinen, Arto Urtti, Arto Urtti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.liebertpub.com/doi/10.1089/jop.1986.2.67
Specifically, this paper will first review and describe (a) the constraints in topical ocular drug delivery, (b) mechanisms and constraints of ocular drug absorption, and (c) mathematics and modelling of ocular drug disposition in order to set the stage for understanding (a) the approaches that can be taken to optimize ocular drug delivery, (b ...Author: Vincent H.L. Lee, Joseph R. Robinson
https://www.deepdyve.com/lp/elsevier/ocular-absorption-following-topical-delivery-adbezbdpko
Ocular absorption following topical delivery Ocular absorption following topical delivery Järvinen, Kristiina; Järvinen, Tomi; Urtti, Arto 1995-08-01 00:00:00 Most ocular diseases are treated with topical application of eyedrops. After instillation of an eyedrop, typically less than 5% of the applied drug penetrates the cornea and reaches intraocular tissues, while a major fraction of the ...
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0420.2007.00885.x
Aug 20, 2007 · We examined the relative roles of topical and systemic absorption in drug delivery to the retina and other ocular tissues. This study aimed to answer the following questions: (1) What are the relative efficiencies of topical versus systemic absorption of eyedrops in drug delivery to tissues in the anterior and posterior segments of the rabbit eye?Author: Hakon H. Sigurdsson, Fífa Konráðsdóttir, Thorsteinn Loftsson, Einar Stefánsson
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0420.2007.00885.x
topical absorption into the eye or sys-temic absorption through the blood-stream (Saari et al. 1993; Vuori et al. 1993). We examined the relative roles of topical and systemic absorption in drug delivery to the retina and other ocular tissues. This study aimed to answer the fol-lowing questions: (1) What are the relative efficienciesAuthor: Hakon H. Sigurdsson, Fífa Konráðsdóttir, Thorsteinn Loftsson, Einar Stefánsson
https://www.dovepress.com/systemic-side-effects-of-eye-drops-a-pharmacokinetic-perspective-peer-reviewed-fulltext-article-OPTH
Systemic side effects of eye drops: a pharmacokinetic perspective Andre Farkouh,1 Peter Frigo,2 Martin Czejka1,3 1Division of Clinical Pharmacy and Diagnostics, Faculty of Life Sciences, University of Vienna, 2Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, 3Austrian Society of Applied Pharmacokinetics, Vienna, Austria Abstract: When ...Author: Andre Farkouh, Peter Frigo, Martin Czejka
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066223/
Feb 01, 2014 · Aqueous Nanomicellar Formulation for Topical Delivery of Biotinylated Lipid Prodrug of Acyclovir: Formulation Development and Ocular Biocompatibility. ... a major issue in the field of ocular drug absorption is poor drug bioavailability from topical instillation that arises from rapid elimination owing to precorneal factors, such as tear ...Author: Aswani Dutt Vadlapudi, Kishore Cholkar, Ramya Krishna Vadlapatla, Ashim K. Mitra
https://freepaper.me/downloads/abstract/10.1016/0169-409X(95)00010-5
Ocular absorption following topical delivery. Most ocular diseases are treated with topical application of eyedrops. After instillation of an eyedrop, typically less than 5% of the applied drug penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is absorbed and enters the systemic circulation.
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