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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The transscleral drug delivery with periocular administration route is evolved as an alternative mode of drug delivery to the posterior ocular tissues. Although transscleral delivery is comparatively easy, less invasive and patient compliant, drug permeation is compromised by ocular static and dynamic barriers.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.allfordrugs.com/ocular-drug-delivery-systems-an-overview/
Ocular iontophoresis offers a drug delivery system that is fast, painless and safe; and in most cases, it results in the delivery of a high concentration of the drug to a specific site. Increased incidence of bacterial keratitis, frequently resulting in corneal scarring, offers a clinical condition that may benefit from drug delivery by iontophoresis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · MICRONEEDLE-, ULTRASOUND-, AND IONTOPHORESIS-BASED OCULAR DRUG DELIVERY SYSTEMS All these delivery systems are noninvasive methods designed to deliver drugs to intraocular regions, mainly for the treatment of posterior segment diseases. Researchers have developed drug-coated microneedles with a length of 500 to 750 µm.Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
http://ijpsr.com/bft-article/ocular-drug-delivery-system-an-overview/?view=fulltext
Ocular Iontophoresis: Lantophoresis is a new concept in ocular drug delivery system in which charged drug molecules are used. Positive charge drug molecules were driven into the tissue at anode and negative charge drug molecule driven respectively at cathode.
https://www.nature.com/articles/s41433-020-0809-0
Feb 18, 2020 · Recent advances in pharmacological agents have led to successful treatment of a variety of retinal diseases such as neovascular age-related macular degeneration (AMD), diabetic macular oedema (DMO ...Author: Jennifer J. Kang-Mieler, Kayla M. Rudeen, Wenqiang Liu, William F. Mieler
https://www.pharmatutor.org/articles/review-on-ocular-drug-delivery
Advantages of ocular drug delivery systems 1. Increased accurate dosing. To overcome the side effects of pulsed dosing produced by conventional systems. 2. To provide sustained and controlled drug delivery. 3. To increase the ocular bioavailability of drug by increasing the corneal contact time.
https://www.ijpbs.com/ijpbsadmin/upload/ijpbs_50c8546501de1.pdf
OCULAR DRUG DELIVERY SYSTEMS: release ocular drug delivery system are: It should not induce a foreign-body sensation or long lasting blurring. It should possess more local activity than systemic-effects. It must deliver the drug to the right place, i.e. in targeting the ciliary body. It …
https://www.researchgate.net/publication/225897418_OCULAR_DRUG_DELIVERY_SYSTEM_-_A_REVIEW
Ocular disposition and elimination of a therapeutic agent is dependent upon its physicochemical properties as well as the relevant ocular anatomy and physiology. A successful design of a drug...
https://www.slideshare.net/vijayalakshmikalaga/ocular-drug-delivery-systems
Sep 17, 2012 · ocular drug delivery systems 1. INTRODUCTION Ocular administration of drug isprimarily associated with the need totreat ophthalmic diseases. Eye is the most easily accessible site fortopical administration of a medication. Ideal ophthalmic drug delivery mustbe able to sustain the drug release andto remain in the vicinity of front of theeye for prolong period of time.
https://www.sciencedirect.com/science/article/pii/S1350946297000025
This chapter will focus on three representative areas of ophthalmic drug delivery systems: polymeric gels, colloidal systems, cyclodextrins and collagen shields. Hydrogels generally offer a moderate improvement of ocular drug bioavailability with the disadvantage of blurring of vision.Author: Chrystèle Le Bourlais, Liliane Acar, Hosein Zia, Pierre A. Sado, Thomas Needham, Roger Leverge
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