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https://www.sciencedirect.com/science/article/pii/S0378517309007583
Jan 29, 2010 · Novel pMDI formulations for pulmonary delivery of proteins 1. Introduction. The relatively large alveolar surface area (approximately 150 m 2 ),... 2. Materials and methods. Bovine serum albumin (BSA, molecular weight 66 kDa)... 3. Results and discussion. Increasing the amount of NaCMC added to ...Author: Hao-Ying Li, Peter C. Seville
https://www.researchgate.net/publication/38033709_Novel_pMDI_formulations_for_pulmonary_delivery_of_proteins
Thus, formulation of pMDI suspensions using NaCMC-based spray-dried powders is a promising approach for the pulmonary delivery of proteins and peptides.
http://eprints.worc.ac.uk/8183/
Thus, formulation of pMDI suspensions using NaCMC-based spray-dried powders is a promising approach for the pulmonary delivery of proteins and peptides.Author: Hao-Ying Li, Peter C. Seville
https://core.ac.uk/display/78895330
In this paper, we demonstrate that co-spray-drying a model protein with sodium carboxymethylcellulose (NaCMC) protects protein integrity during spray-drying, and that the resultant spray-dried powders can be successfully dispersed in hydrofluoroalkane (HFA) propellant to prepare pressurised metered dose (pMDI) formulations that exhibit high respirable fractions.Author: Hao-Ying Li and Peter C. Seville
https://www.deepdyve.com/lp/elsevier/novel-pmdi-formulations-for-pulmonary-delivery-of-proteins-Hni0luMau0
Jan 29, 2010 · Novel pMDI formulations for pulmonary delivery of proteins Li, Hao-Ying; Seville, Peter C. 2010-01-29 00:00:00 In this paper, we demonstrate that co-spray-drying a model protein with sodium carboxymethylcellulose (NaCMC) protects protein integrity during spray-drying, and that the resultant spray-dried powders can be successfully dispersed in hydrofluoroalkane (HFA) propellant to prepare …
https://journal.pda.org/content/65/5/513
Sep 01, 2011 · The delivery device plays a major role in the efficiency of pulmonary delivery, and great strides have been made in the development of new devices in recent years. The devices most commonly used for respiratory delivery, including nebulizers, metered-dose inhalers, and dry powder inhalers, can all be adapted for use with protein/peptide drugs.Author: Basavaraj K. Nanjwade, Sagar A. Adichwal, Kishori R. Gaikwad, Kemy A. Parikh, F. V. Manvi
https://www.sciencedirect.com/science/article/pii/B9780123849359100021
Clinical Applications of Pulmonary Protein Delivery 24 2.2.1. Local and Systemic Delivery via Inhalation 24. 2.2.2. Absorption and Bioavailability from the Lungs 25. 2.2.3. Safety of Inhaled Proteins and Peptides 27. 2.2.4. Types of Proteins and Peptides for Inhalation 28. 2.3. Stability of Proteins and Peptides in Pulmonary Delivery Formulations 28Author: Philip Chi Lip Kwok, Hak-Kim Chan
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
The review is prepared with an aim to discuss about the technical, physiological, and efficacy aspects of the novel pulmonary route of drug targeting and different delivery devices such as metered dose inhalers (MDI), dry powder inhalers (DPI), nebulizers, etc.
https://www.researchgate.net/publication/233680945_Liquid-Spray_or_Dry-Powder_Systems_for_Inhaled_Delivery_of_Peptide_and_Proteins
Thus, formulation of pMDI suspensions using NaCMC-based spray-dried powders is a promising approach for the pulmonary delivery of proteins and peptides.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334339/
Feb 12, 2015 · The pulmonary route of administration has proven to be effective in local and systemic delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non-pulmonary diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient.Author: Mariam Ibrahim, Rahul Verma, Lucila Garcia-Contreras
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