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https://www.ncbi.nlm.nih.gov/pubmed/17598283
Novel enhanced delivery taxanes: an update. ... Enhanced-delivery taxanes (EDTs) were specifically designed to improve the efficacy and tolerability of taxanes through the utilization of biocompatible, tumor-selective, taxane delivery vehicles, removing the need for drug delivery in toxic, conventional solvents. ...Author: Edith A. Perez
https://mayoclinic.pure.elsevier.com/en/publications/novel-enhanced-delivery-taxanes-an-update
Taxanes are widely used for many solid tumors, including metastatic breast cancer. Enhanced-delivery taxanes (EDTs) were specifically designed to improve the efficacy and tolerability of taxanes through the utilization of biocompatible, tumor-selective, taxane delivery vehicles, removing the need for drug delivery in toxic, conventional solvents.Author: Edith A. Perez
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910952/
Solubility measurements. The solubility of PTX, VE-PTX and LA-PTX in VE and LA was determined using a saturation method. Briefly, excess PTX or PTX conjugates (trace amount of 3 H-PTX or 3 H-PTX-LA was mixed inside) in chloroform was mixed with a VE or LA chloroform solution. The chloroform was then evaporated using a nitrogen gas flow keeping the mixtures under a vacuum in a desiccator for 12 h.Author: Dun Wang, Qiang Fu, Jingling Tang, Michael Hackett, Yongjun Wang, Feng Liu
https://www.sciencedirect.com/science/article/pii/S0378517317311183
Taxanes are a class of widely used potent anticancer agents, which include paclitaxel (PTX), docetaxel (DTX), and other taxane-skeleton-containing analogues (Brunetti et al., 2015, Joerger, 2016, Liu et al., 2008, Nieuweboer et al., 2014).These drugs were shown to have a broad range of anticancer activities against breast, lung, pancreatic, prostate, ovarian, and head and neck cancers (Conlin ...Author: Mohammad M. Kamal, Sami Nazzal
https://www.researchgate.net/publication/6635890_Taxanes_in_breast_cancer_An_update
Taxanes in breast cancer: An update. ... the use of chemotherapy and hopefully lead the way to novel targeted options that include immunotherapy. ... enhanced drug delivery to tumors when ...
https://link.springer.com/article/10.1007/s11095-012-0775-8
May 17, 2012 · Nanoparticulate paclitaxel carriers have entered clinical evaluation as alternatives to the Cremophor-based standard Taxol® (Cre-pac). Their pharmacokinetics (PK) is complex, and factors influencing their pharmacodynamics (PD) are poorly understood. We aimed to develop a unified quantitative model for 4 paclitaxel carriers that captures systems-level PK, predicts micro-scale PK …Author: Sihem Ait-Oudhia, Robert M. Straubinger, Donald E. Mager
https://clincancerres.aacrjournals.org/content/14/6/1610
Mar 15, 2008 · The plasticity and instability of the cancer genome is impressive and is characterized by gene amplifications and deletions, rearrangements, and many silent and active mutations. Although targeted therapeutics have had effect in some diseases, there remains a large role for new cytotoxic agents that have the potential to be broadly active across multiple cancers. Platinum-based regimens …Author: Beverly A. Teicher
https://www.researchgate.net/publication/5845862_Enhanced_efficiency_of_thermally_targeted_taxanes_delivery_in_a_human_xenograft_model_of_gastric_cancer
Enhanced efficiency of thermally targeted taxanes delivery in a human xenograft model of gastric cancer Article in Journal of Pharmaceutical Sciences 97(8):3170-81 · August 2008 with 17 Reads
https://www.sciencedirect.com/science/article/pii/S0026286209000211
The latest development of taxanes possessing enhanced delivery and decreased toxicity properties (Perez, 2007) may facilitate the use of this approach in the nearest future. Adhesion complexes and increased transendothelial permeabilityAuthor: Natalia V. Bogatcheva, Alexander Dmitriyevich Verin
https://clincancerres.aacrjournals.org/content/21/4/795
Feb 15, 2015 · Purpose: To improve the outcomes of patients with castration-resistant prostate cancer (CRPC), there is an urgent need for more effective therapies and approaches that individualize specific treatments for patients with CRPC. These studies compared the novel taxane cabazitaxel with the previous generation docetaxel, and aimed to determine which tumors are most likely to respond. …Author: Renée de Leeuw, Lisa D. Berman-Booty, Matthew J. Schiewer, Stephen J. Ciment, Robert B. Den, Adam P....
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