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https://pubs.acs.org/doi/10.1021/jm901022t
Gene therapy based on gene delivery is a promising strategy for the treatment of human disease. Here we present data on structure/biological activity of new biodegradable cholesterol-based cationic lipids with various heterocyclic cationic head groups and linker types. Enhanced accumulation of nucleic acids in the cells mediated by the lipids was demonstrated by fluorescent microscopy and flow ...Author: Darya A. Medvedeva, Mikhail A. Maslov, Roman N. Serikov, Nina G. Morozova, Galina A. Serebrenikova, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394498/
The design, synthesis and biological evaluation of the cationic lipid gene delivery vectors based on cholesterol and natural amino acids lysine or histidine are described. Cationic liposomes composed of the newly synthesized cationic lipids 1a or 1b and ...Author: Jia Ju, Meng-Lei Huan, Ning Wan, Hai Qiu, Si-Yuan Zhou, Bang-Le Zhang
https://www.sciencedirect.com/science/article/pii/S0960894X09005496
Among these components, the cholesterol-based cationic lipid has been used as the major lipid of liposomes for the delivery of genes 11 and chemical drugs12, 13 due to it being less toxic than other cationic lipids. 14 The capacity of the gene delivery using these cationic lipids depends on the combination of cationic head, degree of ...Author: Bieong-Kil Kim, Kyung-Oh Doh, Joo Hyeung Nam, Hyungu Kang, Jong-Gu Park, Ik-Jae Moon, Young-Bae Seu
https://www.researchgate.net/publication/26890286_Novel_Cholesterol-Based_Cationic_Lipids_for_Gene_Delivery
Gene therapy based on gene delivery is a promising strategy for the treatment of human disease. Here we present data on structure/biological activity of new biodegradable cholesterol-based ...
https://pubs.acs.org/doi/pdf/10.1021/jm901022t
Gene therapy based on gene delivery is a promising strategy for the treatment of human disease. Here we present data on structure/biological activity of new biodegradable cholesterol-based cationic lipids with various heterocyclic cationic head groups and linker types.
https://pdfs.semanticscholar.org/e7a1/8bedf818fda0e48984fdc90fadc8b09d6572.pdf
Novel Cholesterol-Based Cationic Lipids as Transfecting Agents of DNA for Efficient Gene Delivery Jia Ju †, Meng-Lei Huan †, Ning Wan, Hai Qiu, Si-Yuan Zhou and Bang-Le Zhang * Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University,
https://www.researchgate.net/publication/24396598_Synthesis_of_novel_cholesterol-based_cationic_lipids_for_gene_delivery
Synthesis of novel cholesterol-based cationic lipids for gene delivery Article in Bioorganic & medicinal chemistry letters 19(11):2986-9 · July 2009 with 21 Reads How we measure 'reads'
https://www.mdpi.com/1422-0067/16/3/5666
The design, synthesis and biological evaluation of the cationic lipid gene delivery vectors based on cholesterol and natural amino acids lysine or histidine are described. Cationic liposomes composed of the newly synthesized cationic lipids 1a or 1b and neutral lipid DOPE (1,2-dioleoyl-l-α-glycero-3-phosphatidyl-ethanolamine) exhibited good transfection efficiency. pEGFP-N1 plasmid DNA was ...Author: Jia Ju, Meng-Lei Huan, Ning Wan, Hai Qiu, Si-Yuan Zhou, Bang-Le Zhang
https://www.nature.com/articles/3301471
Jun 22, 2001 · The synthesis of a series of novel cationic lipids through the systematic substitution of cholesterol derivatives that could greatly enhance the delivery and expression of plasmid DNA in …Author: H Gao, K M Hui
https://www.ncbi.nlm.nih.gov/pubmed/10543873
Oct 21, 1999 · Novel series of non-glycerol-based cationic transfection lipids for use in liposomal gene delivery. Banerjee R(1), Das PK, Srilakshmi GV, Chaudhuri A, Rao NM. Author information: (1)Centre for Cellular & Molecular Biology, Hyderabad 500 007, India.Author: Rajkumar Banerjee, Prasanta Kumar Das, Gollapudi Venkata Srilakshmi, Arabinda Chaudhuri, Nalam Madhu...
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