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https://www.researchgate.net/publication/12632402_Non-Viral_Peptide-Based_Approaches_to_Gene_Delivery
Non-Viral Peptide-Based Approaches to Gene Delivery Article · Literature Review (PDF Available) in Journal of Drug Targeting 7(4):249-68 · January 2000 with 97 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
https://www.tandfonline.com/doi/abs/10.3109/10611869909085509
Jun 26, 2009 · Non-Viral Peptide-Based Approaches to Gene Delivery Ram I. Mahato Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Biomedical Polymer Building, 20S 2030E, Room # 205, Salt Lake City, UT, 84112-9452, USA Correspondence [email protected]: Ram I. Mahato
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
3.2.3. Peptide-based gene non-viral vectors. Many types of peptides, which are generally cationic in nature and able to interact with plasmid DNA through electrostatic interaction, are under intense investigation as a safe alternative for gene therapy . There are mainly four barriers that must be overcome by non-viral vectors to achieve ...Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · Poly-l-lysine (PLL) is a peptide-based polymer, and was one of the first polymers utilized as a non-viral gene delivery vector. Its peptide structure allows ease of biodegradability and complexes with plasmid DNA to transfect cells.Author: Michael K. Riley, Wilfred Vermerris
https://www.researchgate.net/publication/14109627_Nonviral_Vectors_for_In_Vivo_Gene_Delivery_Physicochemical_and_Pharmacokinetic_Considerations
Nonviral Vectors for In Vivo Gene Delivery: Physicochemical and Pharmacokinetic Considerations. ... Non-Viral Peptide-Based Approaches to Gene Delivery ... Synthetic peptide-based gene delivery ...
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(03)00005-4
The major disadvantage of using non-viral DNA delivery vectors, compared with their viral counterparts, is the low transfection efficiency. This has resulted in low levels of usage in clinical trials. Consequently, the majority of research into non-viral gene therapy has been focused on developing more efficient vectors.Author: Gabriele D Schmidt-Wolf, Ingo G.H Schmidt-Wolf
https://www.sciencedirect.com/science/article/pii/S0168365901004916
A second family of gene delivery strategies encompasses all non-viral approaches where DNA is either physically delivered to cells or non-covalently associated with molecular aggregates such as liposomes or polymers such as poly-l-lysine , acting as cell import agents. For example, DNA is typically compacted by cationic agents such as ...Author: Richard D Brokx, Stuart K Bisland, Jean Gariépy
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