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https://www.researchgate.net/publication/221883992_Nanowired_Drug_Delivery_to_Enhance_Neuroprotection_in_Spinal_Cord_Injury
Nanowired Drug Delivery to Enhance Neuroprotection in Spinal Cord Injury Article · Literature Review in CNS & neurological disorders drug targets 11(1):86-95 · February 2012 with 44 Reads
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1871-5273&volume=11&issue=1&spage=86
In addition, nanowired drugs may penetrate the CNS faster and could reach widespread areas once entering the spinal cord. Thus, nanowired drug delivery to treat SCI may have potential therapeutic value. These aspects of nanowired drug delivery to enhance neuroprotection in SCI are discussed in this review based on our own investigations.
https://www.ncbi.nlm.nih.gov/pubmed/21161717
Spinal cord injury (SCI) is a devastating disease that leads to permanent disability of victims for which no suitable therapeutic intervention has been achieved so far. Thus, exploration of novel therapeutic agents and nano-drug delivery to enhance neuroprotection after SCI is the need of the hour.Author: Hari Shanker Sharma
https://www.researchgate.net/publication/40021666_Nano-Drug_Delivery_and_Neuroprotection_in_Spinal_Cord_Injury
Nano-Drug Delivery and Neuroprotection in Spinal Cord Injury Article in Journal of Nanoscience and Nanotechnology 9(8):5014-37 · August 2009 with 84 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pubmed/22162425
These two factors enhance neuroprotection than the conventions drug delivery. However, this is still uncertain whether nanodrug delivery could alter the pharmacokinetics of compounds making it more effective or just longer exposure of the compound for extended period of time is primarily responsible for enhanced effects of the drugs.Author: Hari Shanker Sharma, Aruna Sharma
http://www.diva-portal.org/smash/record.jsf?pid=diva2:529749
In addition, nanowired drugs may penetrate the CNS faster and could reach widespread areas once entering the spinal cord. Thus, nanowired drug delivery to treat SCI may have potential therapeutic value. These aspects of nanowired drug delivery to enhance neuroprotection in SCI are discussed in this review based on our own investigations. Place ...
https://link.springer.com/article/10.1007/s12035-015-9298-8
Jul 01, 2015 · Sharma HS (2011) Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection. J Neural Transm 118(1):155–176. doi: 10.1007/s00702-010-0514-4 CrossRef PubMed Google ScholarAuthor: Dafin F. Muresanu, Aruna Sharma, Aruna Sharma, José V. Lafuente, Ranjana Patnaik, Z. Ryan Tian, Fred...
https://www.sciencedirect.com/science/article/pii/S0074774219300297
Topical application of nanowired DL-NBP alone is also able to enhance spinal cord conduction after injury but the magnitude and intensity of the effects are much lower. This suggests that apart from drug effects, titanium implants with TiO 2 nanowires significantly potentiated the nanowired NBP effects on spinal cord conduction.Author: Seaab Sahib, Feng Niu, Aruna Sharma, Lianyuan Feng, Z. Ryan Tian, Dafin F. Muresanu, Ala Nozari, Har...
https://www.sciencedirect.com/science/article/pii/S0079612309175088
Traumatic spinal cord injury triggers a complex local inflammatory reaction capable of enhancing repair and exacerbating pathology. The composition and effector potential of the post-injury cellular and molecular immune cascade changes as a function of time and distance from the lesion.Author: Jessica K. Alexander, Phillip G. Popovich
https://onlinelibrary.wiley.com/doi/full/10.1002/wnan.172
Our laboratory is engaged in understanding of the nanodrug delivery using TiO 2 nanowires in CNS injuries models, for example, spinal cord injury (SCI), hyperthermia and/or intoxication of nanoparticles with or without other comorbidity factors, that is, diabetes or hypertension in rat models. Our observations suggest that nanowired drug ...Author: Hari Shanker Sharma, Aruna Sharma
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