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https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201906187?af=R
Simple and Efficient Targeted Intracellular Protein Delivery with SelfâAssembled Nanovehicles for Effective Cancer Therapy Xiao He School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331 P. R. ChinaAuthor: Xiao He, Qipeng Long, Zhiying Zeng, Lan Yang, Yaqin Tang, Xuli Feng
https://pubs.acs.org/doi/10.1021/acs.accounts.8b00493
ConspectusThe use of protein to precisely manipulate cell signaling is an effective approach for controlling cell fate and developing precision medicine. More recently, programmable nucleases, such as CRISPR/Cas9, have shown extremely high potency for editing genetic flow of mammalian cells, and for treating genetic disorders. The therapeutic potential of proteins with an intracellular target ...Author: Jin Chang, Xianghan Chen, Xianghan Chen, Zachary Glass, Feng Gao, Lanqun Mao, Ming Wang, Qiaobing Xu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207587/
Oct 24, 2018 · Based on Sesbania mosaic virus coat protein modified with IgG binding protein A B-domain self-assembling virus-like particles, this platform for intracellular delivery of antibodies proved to be effective for intracellular delivery of three different mAbs, which exerted their biological effects owing to respective epitope binding (Abraham et al ...Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.sciencedirect.com/science/article/pii/S0168365911000368
The past couple of years have witnessed a tremendous progress in the development of glutathione-responsive nano-vehicles for targeted intracellular drug and gene delivery, as driven by the facts that (i) many therapeutics (e.g. anti-cancer drugs, photosensitizers, and anti-oxidants) and biotherapeutics (e.g. peptide and protein drugs, and siRNA) exert therapeutical effects only inside cells ...Author: Ru Cheng, Fang Feng, Fenghua Meng, Chao Deng, Jan Feijen, Zhiyuan Zhong
https://www.thno.org/v09p3280.htm
2. Strategies for protein delivery. The cell membrane separates the interior of the cells from the extracellular environment and thus creates a discrete partition between internal and external environments [] that limits direct intracellular delivery of most compounds to only small molecules and ions capable of membrane diffusion [].Large molecules such as proteins, polypeptides, and ...
https://www.sciencedirect.com/science/article/pii/S0958166917302185
Intracellular protein delivery and vaccine development. Vaccines are arguably the most effective class of therapeutics ever developed. However, despite their success, vaccines still need to be developed for many pathogens, ranging from HIV to Hepatitis C. CD8 + T cells play an essential role in combating infections generated from viruses and cancer and there is consequently great interest in ...Author: Yumiao Zhang, Joachim Justad Røise, Kunwoo Lee, Jie Li, Niren Murthy
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