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https://www.ncbi.nlm.nih.gov/pubmed/21320582
Sep 20, 2011 · SiRNA delivery with functionalized carbon nanotubes. Varkouhi AK(1), Foillard S, Lammers T, Schiffelers RM, Doris E, Hennink WE, Storm G. Author information: (1)Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.Author: Amir Khashayar Varkouhi, Stéphanie Foillard, Twan Lammers, Twan Lammers, Raymond M. Schiffelers, Eri...
https://advances.sciencemag.org/content/5/9/eaaw6499.full
Sep 01, 2019 · RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)–assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacting protein kinase 4 ( RIPK4 ) efficiently silenced its expression to …Author: Jianye Liu, Yi Zhang, Qinghai Zeng, Hongliang Zeng, Xiaoming Liu, Pei Wu, Hongyi Xie, Leye He, Zhi L...
https://pubs.acs.org/doi/abs/10.1021/bc500280q
siRNA can downregulate the expression of specific genes. However, delivery to specific cells and tissues in vivo presents significant challenges. Modified carbon nanotubes (CNTs) have been shown to protect siRNA and facilitate its entry into cells. However, simple and efficient methods to functionalize CNTs are needed. Here, noncovalent functionalization of CNTs is performed and shown to ...Author: King S. Siu, Xiufen Zheng, Yanling Liu, Yujuan Zhang, Xusheng Zhang, Di Chen, Ken Yuan, Elizabeth R....
https://www.researchgate.net/publication/49835600_SiRNA_delivery_with_functionalized_carbon_nanotubes
The conjugation of siRNA to functionalized carbon nanotubes (f-CNTs) significantly increases their delivery into cells due to CNT uptake through mechanisms other than endocytosis [10]. On the ...
https://www.sciencedirect.com/science/article/pii/S0142961213015755
RNAi can specifically regulate gene expression, but efficient delivery of siRNA in vivo is difficult while it has been shown that modified carbon nanotubes (CNT) protect siRNA, facilitate entry into cells and enhance transdermal drugs delivery. Single-walled carbon nanotubes (SWCNT) were functionalized non-covalently with succinated polyethyleimine (PEI-SA).Author: King Sun Siu, Di Chen, Xiufen Zheng, Xusheng Zhang, Nathan Johnston, Yanling Liu, Ken Yuan, James Ko...
https://www.sciencedirect.com/science/article/pii/S0378517311001256
Sep 20, 2011 · Carbon nanotubes (CNTs) have been studied for drug, antigen and nucleic acid delivery both in vitro and in vivo. Due to their nano-needle structure, they are supposed to cross the plasma membrane and enter directly into the cytoplasm likely upon an endocytosis-independent mechanism without inducing cell death.Author: Amir Khashayar Varkouhi, Stéphanie Foillard, Twan Lammers, Twan Lammers, Raymond M. Schiffelers, Eri...
https://www.biorxiv.org/content/10.1101/564427v1
Mar 01, 2019 · Herein, we develop a nanotube-based platform for direct delivery of siRNA, and show high silencing efficiency in intact plant cells. We demonstrate that nanotubes successfully deliver siRNA and silence endogenous genes owing to effective intracellular delivery and nanotube-induced protection of siRNA from nuclease degradation.Author: Gozde Demirer, Huan Zhang, Natalie Goh, Roger Chang, Markita Landry
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475451/
Carbon nanotubes (CNT) have recently been studied as novel and versatile drug and gene delivery vehicles. When CNT are suitably functionalized, they can interact with various cell types and are taken up by endocytosis.Anti-cancer drugs cisplatin and doxorubicin ...Author: Mahdi Karimi, Navid Solati, Amir Ghasemi, Mehrdad Asghari Estiar, Mahshid Hashemkhani, Parnian Kiani...
https://pubs.acs.org/doi/10.1021/ja903316z
Highlighting the Role of Polymer Length, Carbohydrate Size, and Nucleic Acid Type in Potency of Glycopolycation Agents for pDNA and siRNA Delivery. Biomacromolecules 2013, 14 (11) , 3903-3915. DOI: 10.1021/bm401026n. Peng Liu . Modification Strategies for Carbon Nanotubes as a …Author: M. Antonia Herrero, Francesca M. Toma, Khuloud T. Al-Jamal, Kostas Kostarelos, Alberto Bianco, Tatia...
https://advances.sciencemag.org/content/advances/5/9/eaaw6499.full.pdf
(HNT)–assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacting protein kinase 4 (RIPK4) efficiently silenced its expression to treat bladder cancer. The HNTs/siRNA complex increased the serum stability of the siRNA, increased its circulation lifetime in blood, and promoted the cellular uptake and tumorAuthor: Jianye Liu, Yi Zhang, Qinghai Zeng, Hongliang Zeng, Xiaoming Liu, Pei Wu, Hongyi Xie, Leye He, Zhi L...
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