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https://www.ncbi.nlm.nih.gov/pubmed/19488722
Nonviral gene delivery has been gaining considerable attention recently. Although the efficacy of DNA transfection, which is a major concern, is low in nonviral vector-mediated gene transfer compared with viral ones, nonviral vectors are relatively easy to prepare, less immunogenic and oncogenic, and have no potential of virus recombination and ...Author: Sha Jin, John C. Leach, Kaiming Ye
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · Nanoparticles in gene delivery. In the field of nanomedicine, nanotechnology methods focus on formulating therapeutic biocompatible agents such as nanoparticles, nanocapsules, micellar systems, and conjugates [22,23].Nanoparticles are solid and spherical structures ranging to around 100 nm in size and prepared from natural or synthetic polymers [].Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
https://www.sciencedirect.com/science/article/pii/B9780081005576000043
From these studies, it has been postulated that bioreducible cross-linked polymeric nanoparticles have been shown as efficient and safe gene delivery vehicles because of their stability in an extracellular medium and rapid degradation in a reductive intracellular environment which facilitates release of the bound DNA for nuclear localization.Author: Manohar Mahato, Ashwani Kumar Sharma, Pradeep Kumar
https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
Polymeric Nanoparticles for Gene Delivery. The aim of this study is to investigate the structure-transfection efficiency relationship of PPA gene carriers; and to investigate the effect of PPA structure on DNA compaction ability of PPA, stability of PPA/DNA nanoparticles in physiological medium, cellular uptake efficiency, intracellular ...
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/medicated-nanoparticle-for-gene-delivery
The basic mechanism involved in the gene delivery is an introduction of a gene encoding a functional protein altering the expression of an endogenous gene or owning the capacity to cure or prevent the progression of a disease. Nanoparticle surface features like particle shape and surface charge are having major roles in the gene delivery.Author: Sakthivel Lakshmana Prabu, Timmadonu Narasimman KuppusamiSuriyaprakash, Rathinasabapathy Thirumuruga...
https://www.researchgate.net/publication/7141587_Nanoparticles_for_Gene_Delivery
Nanoparticles for Gene Delivery. ... produced under GMP conditions from fungal source was used to encapsulate a plasmid DNA coding for a reporter gene. Nanoparticles made by complex coacervation ...
https://pubs.acs.org/doi/10.1021/acsami.9b00704
Multifunctional hybrid nanoparticles are being developed to carry a wide variety of therapeutic and imaging agents for multiple biomedical applications. Polysilsesquioxane (PSilQ) nanoparticles are a promising hybrid platform with numerous advantages to be used as a delivery system. In this report, we demonstrate the ability of a stimuli-responsive PSilQ-based platform to transport and deliver ...Author: Ridhima Juneja, Zachary Lyles, Hemapriyadarshini Vadarevu, Kirill A. Afonin, Juan L. Vivero-Escoto
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30165-6
Jan 01, 2016 · Nanoparticles have been proved to be the most promising vehicles for clinical gene therapy due to their tunable size, shape, surface, and biological behaviors. In this review, the clinical development of nanoparticles for gene delivery will be particularly highlighted.Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://www.sciencedirect.com/science/article/pii/S0169409X02002284
Intracellular delivery is also important for gene therapy approaches to achieve greater level of gene expression. Since the drug/gene is encapsulated in nanoparticles, it is also protected from rapid enzymatic/hydrolytic degradation, an advantage over a free drug/gene in solution.Author: Jayanth Panyam, Vinod D Labhasetwar
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