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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693026/
Jun 18, 2013 · Nanoparticles (NPs) have been designed to overcome the barriers, increase the drug penetration at the target site and prolong the drug levels by few internals of drug administrations in lower doses without any toxicity compared to the conventional eye drops.Author: Hong-Yan Zhou, Ji-Long Hao, Shuang Wang, Yu Zheng, Wen-Song Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617524/
Therefore, transporter-targeted prodrug strategy can improve drug delivery to ocular tissue by enhanced absorption of poorly permeating parent drugs. 22,28 Acyclovir (ACV) is an anti-viral drug, with a poor aqueous solubility and low corneal permeability. Therefore, a prodrug strategy was adopted to improve corneal absorption of ACV.
https://www.sciencedirect.com/science/article/pii/S0378517317308724
Topically-applied dosage forms, such eye drops, are the most used formulations in the treatment of ocular diseases. Nonetheless, because of the special protection of the eye associated with the ocular surface, drug bioavailability and subsequent therapeutic efficiency obtained with these conventional dosage forms are very low.Author: Jesus Alvarez-Trabado, Jesus Alvarez-Trabado, Yolanda Diebold, Yolanda Diebold, Alejandro Sanchez
http://www.nanovexbiotech.com/plga-nanoparticles-ocular-drug-delivery/
Nov 14, 2017 · PLGA nanoparticles in the ocular drug delivery The topical ocular administration of drugs has two different purposes: to treat superficial eye diseases, such as infections (e.g. conjunctivitis, blepharitis, keratitis sicca) and to provide intraocular treatment through …
https://www.researchgate.net/publication/281082598_Nanoparticles_for_Ocular_Drug_Delivery
The major goal in ocular drug delivery is to obtain therapeutic drug concentrations at the intended site of action for a reasonable period of time by overcoming biological barriers.
https://www.tandfonline.com/doi/abs/10.1080/17425247.2016.1201059
Nov 18, 2016 · Lipid nanoparticles are potential alternatives to ocular administration mainly due to their capacity for increasing the residence time and bioavailability of the drugs The main issue addressed by lipid nanoparticles for ocular topical route is overcoming the corneal barriers and increasing corneal retentionAuthor: Luigi Battaglia, Loredana Serpe, Federica Foglietta, Elisabetta Muntoni, Marina Gallarate, Ana Del P...
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