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https://www.ncbi.nlm.nih.gov/pubmed/18095928
Since its discovery, insulin remains the major treatment for Type 1 diabetes and many Type 2 diabetic patients, with insulin being administered parenterally. The oral route of insulin delivery, being the most comfortable, would also be the most physiologically advantageous in taking advantage of the portal-hepatic route of absorption.Author: Christiane Damgé, Catarina Pinto Reis, Philippe Maincent
https://www.researchgate.net/publication/5753004_Nanoparticle_strategies_for_the_oral_delivery_of_insulin
Nanoparticle strategies for the oral delivery of insulin Article · Literature Review (PDF Available) in Expert Opinion on Drug Delivery 5(1):45-68 · February 2008 with 1,174 Reads
https://www.researchgate.net/profile/Catarina_Reis/publication/5753004_Nanoparticle_strategies_for_the_oral_delivery_of_insulin/links/55954af508ae99aa62c6daa1/Nanoparticle-strategies-for-the-oral-delivery-of-insulin.pdf
Nanoparticle strategies for the oral delivery of insulin 2 Expert Opin. Drug Deliv. (2008) 5(1) to have been the dream since the discovery of insulin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619439/
Oct 24, 2015 · At this juncture, researchers are trying to develop different insulin delivery systems, especially through oral and pulmonary route using nanocarrier based delivery system. This next generation efficient therapy for T1DM may help to improve the quality of life of diabetic patients who routinely employ insulin by the subcutaneous route.Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
https://www.tandfonline.com/doi/abs/10.1517/17425247.5.1.45
Since its discovery, insulin remains the major treatment for Type 1 diabetes and many Type 2 diabetic patients, with insulin being administered parenterally. The oral route of insulin delivery, being the most comfortable, would also be the most physiologically advantageous in taking advantage of the portal–hepatic route of absorption. However, insulin is less absorbed by the intestinal ...Author: Christiane Damgé, Catarina Pinto Reis, Philippe Maincent
https://www.sciencedirect.com/science/article/pii/S0168365917308283
4. Barriers to oral delivery of insulin nanoparticle formulation. Effective oral delivery of insulin remains a significant challenge due to a few physiological barriers. The major barriers to oral administration of insulin can be classified as physical, chemical and enzymatic.Author: Chun Y. Wong, Hani Al-Salami, Crispin R. Dass
https://www.sciencedirect.com/science/article/pii/S073497501500035X
Polymer-based nanoparticles for oral insulin delivery: Revisited approaches ... other companies trying their efforts to achieve a good polymer-based nanoparticle system for the oral delivery of insulin such as Aphios Corp. (Woburn, MA, USA) and NOD Pharmaceuticals, Inc. (San Diego, CA, USA), however the information about the used polymers and ...Author: Pedro Fonte, Francisca Araújo, Cátia Silva, Carla Pereira, Salette Reis, Hélder A. Santos, Bruno Sar...
https://www.onlinelibrary.wiley.com/doi/full/10.1111/jphp.12852
Nov 28, 2017 · This review summarizes the rationale for oral insulin administration, existing barriers and some counter‐strategies trialled. Key findings. Oral insulin mimics the physiology of endogenous insulin secreted by pancreas. Following the intestinal absorption of oral insulin, it reaches the liver at high concentration via the portal vein.Author: Ahmed Gedawy, Jorge Martinez, Hani Al‐Salami, Crispin R. Dass
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/nanoparticle-insulin-drug-delivery-applications-and-new-aspects
Nanoparticle Insulin Drug Delivery — Applications and New Aspects. ... In order to overcome the problems associated with parenteral administration of insulin several strategies that are based on nanotechnology has been developed to enhance the intestinal absorption of different protein and peptides. ... Oral insulin delivery with SLNs ...Author: Hatice Kübra Elçioğlu, Ali Demir Sezer
https://pubs.acs.org/doi/full/10.1021/bm0703923
Nanoparticle strategies for the oral delivery of insulin. Expert Opinion on Drug Delivery 2008, 5 (1) , 45-68. DOI: 10.1517/17425247.5.1.45. Christiane Damgé, Catarina Pinto Reis, Philippe Maincent. Nanoparticle strategies for the oral delivery of insulin.Author: Bruno Sarmento, António Ribeiro, Francisco Veiga, Domingos Ferreira, Ronald Neufeld
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