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https://www.sciencedirect.com/science/article/pii/S1773224717304513
Recent advances in nanoparticle-mediated drug delivery. ... Nanoparticle drug delivery systems in chemotherapy of tuberculosis. ... Nanoparticle-mediated drug delivery represents one promising scheme to successfully increase the CNS penetration for the diagnosis and treatment of neurodegenerative disorders such as Alzheimer's disease.Author: Bipul Kumar, Kanika Jalodia, Pradeep Kumar, Hemant K. Gautam
https://www.ncbi.nlm.nih.gov/pubmed/32009785
Nov 13, 2019 · Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives. Yang C(1), Merlin D(1)(2). Author information: (1)Institute for Biomedical Sciences, Center for Diagnostics and Therapeutics, Digestive Disease Research Group, Georgia State University, Atlanta, GA 30302, USA.Author: Chunhua Yang, Didier Merlin
https://www.sciencedirect.com/science/article/pii/S0168365916303236
Drug delivery in cases of stroke should take into consideration that TJs are compromised and that there is an initial and late opening of the BBB. The leaky BBB and/or the expression of some receptors onto the luminal side of endothelial cells may stand for an opportunity to …Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624329/
High tumor interstitial pressure and inefficient EPR effect can restrict the drug delivery by nanoparticles. PDT has been shown to improve the nanoparticle-mediated drug delivery by reducing interstitial pressure and enhancing tumor vessel permeability.Author: Vaibhav Mundra, Wei Li, Ram I Mahato
https://www.dovepress.com/nanoparticle-mediated-drug-delivery-systems-for-the-treatment-of-ibd-c-peer-reviewed-article-IJN
Therefore, there is still a need for rationally designed and stable NP drug delivery system that can specifically target drugs to the disease site, prolong the drug’s residence time, and minimize systemic side effects. This review will analyze the current state of …Author: Chunhua Yang, Didier Merlin
https://aiche.onlinelibrary.wiley.com/doi/full/10.1021/bp060348j
A NP‐mediated drug delivery system can significantly eliminate drug or drug carrier side effects. A good example is the first biologically interactive agent, albumin‐bound paclitaxel, an anti‐cancer drug. ABI 007 is encapsulated in a 130 nm NP, designed to avoid solvent‐related toxicities and to deliver paclitaxel to …Author: Sha Jin, Kaiming Ye
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054182
The knockdown resulted in a considerable reduction in P-gp substrate efflux and improved delivery and efficacy of doxorubicin, which we used as a model drug. Our results suggest that a nanoparticle mediated delivery of anti-P-gp siRNA could be a feasible approach to improve the treatment of various diseases in the CNS where drug delivery is ...Author: Jostein Malmo, Axel Sandvig, Axel Sandvig, Kjell Morten Vårum, Sabina P. Strand
https://www.dovepress.com/nanoparticle-mediated-drug-delivery-systems-for-the-treatment-of-ibd-c-peer-reviewed-fulltext-article-IJN
The ultimate goal of NP-mediated drug delivery for IBD is to target the NPs to a specific subtype of inflammation-associated cells. In a breakthrough study, surface-modified nontoxic liposomal nanomaterials illustrated the specific-cell targeting ability of NPs.Author: Chunhua Yang, Didier Merlin
https://www.drugtargetreview.com/article/22289/nanoparticle-mediated-enzyme-delivery-application-cancer-therapy/
Mar 09, 2017 · Enzyme therapy is a promising form of cancer treatment. The specific nature of enzyme and substrate interaction gives enzyme therapy an edge compared to standard non-specific therapies such as radiation and chemotherapy. However, since most of these enzymes are of a foreign nature, the delivery of these immunogenic enzymes has been a challenge.Author: Negin Mokhtari, Mukanth Vaidyanathan, Sadik Esener, Ya-San Yeh
https://link.springer.com/article/10.1007%2Fs00466-013-0953-5
Nov 30, 2013 · Nanoparticle (NP)-mediated drug/gene delivery involves phenomena at broad range spatial and temporal scales. The interplay between these phenomena makes the NP-mediated drug/gene delivery process very complex. In this paper, we have identified four key steps in the NP-mediated drug/gene delivery: (i) design and synthesis of delivery vehicle/platform; (ii) microcirculation …Author: Ying Li, Wylie Stroberg, Tae-Rin Lee, Han Sung Kim, Han Man, Dean Ho, Paolo Decuzzi, Wing Kam Liu
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