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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
Ionizable lipids are an advanced delivery platform of gene therapy that can self-assemble into nanoparticles when mixed with polyanionic nucleic acids. Ionizable cationic lipids with modulated pKa values increase nucleic acid payload and enhance the therapeutic efficacy of gene therapy.Author: Yi Zhao, Leaf Huang
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/medicated-nanoparticle-for-gene-delivery
In the magnetic nanoparticle gene delivery system, the gene directly binds to the magnetic particle or carrier. In magnetic nanoparticle, a magnetic core is coated by a protective layer either by dispersing in a polymer matrix or encapsulated within a polymer/metallic shell, which can be combined with therapeutic agents (carrier/DNA complexes or other drugs) through covalent or noncovalent bond.Author: Sakthivel Lakshmana Prabu, Timmadonu Narasimman KuppusamiSuriyaprakash, Rathinasabapathy Thirumuruga...
https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
Polymeric Nanoparticles for Gene Delivery The aim of this study is to investigate the structure-transfection efficiency relationship of PPA gene carriers; and to investigate the effect of PPA structure on DNA compaction ability of PPA, stability of PPA/DNA nanoparticles in physiological medium, cellular uptake efficiency, intracellular trafficking, DNA unpacking, and nuclear translocation.
https://www.ncbi.nlm.nih.gov/pubmed/19488722
The ability to incorporate genetic materials such as plasmid DNA, RNA, and siRNA into functionalized nanoparticles with little toxicity demonstrates a new era in pharmacotherapy for delivering genes selectively to tissues and cells.Author: Sha Jin, John C. Leach, Kaiming Ye
https://www.nature.com/articles/s41434-019-0117-0
Jan 03, 2020 · The particle size of a PEG-peptide DNA nanoparticle is a key determinant of biodistribution following i.v. dosing. DNA nanoparticles of <100 nm …Author: Basil Mathew, Raghu Ramanathan, Nathan A. Delvaux, Jacob Poliskey, Kevin G. Rice
https://www.nature.com/articles/s41565-020-0669-6?error=cookies_not_supported&code=77395623-c20b-4a56-a39c-72d2c8d16cc2
Sago, C. D. et al. High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing. Proc. Natl Acad. Sci. USA 115 , E9944–E9952 (2018).
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