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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229664/
Jan 30, 2012 · Nanoparticle delivery of a peptide targeting EGFR signaling. Address correspondence to: Leaf Huang, Ph.D., Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.Author: Sang Kyoon Kim, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S0168365911005827
In this paper, we demonstrate the use of a new carrier system (LPH), modified from LPD, for targeted, intracellular delivery of a peptide drug to block an important signaling protein in …Author: Sang Kyoon Kim, Leaf Huang
https://www.researchgate.net/publication/51599557_Nanoparticle_delivery_of_a_peptide_targeting_EGFR_signaling
Download Citation Nanoparticle delivery of a peptide targeting EGFR signaling EGFR serves as an important therapeutic target because of its over-expression in many cancers.
http://europepmc.org/abstract/MED/21871507
Feb 01, 2012 · EGFR serves as an important therapeutic target because of its over-expression in many cancers. In this study, we investigated a peptide-based therapy aimed at blocking intracellular protein-protein interactions during EGFR signaling and evaluated a targetable lipid carrier system that can deliver peptides to intracellular targets in human cancer cells.
https://www.sciencedirect.com/science/article/pii/S0304383512003965
LCC EV nanoparticle treatment provoked severe apoptotic effects in H460 non-small cell lung cancer cells in vitro. LCC NPs also mediated the specific delivery of Alexa-488-EV peptide to tumor tissue in vivo, provoking a high tumor growth retardation effect with …Author: Sang Kyoon Kim, Michael B. Foote, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496799/
Jul 01, 2013 · Intracellular therapeutic peptide delivery is a particularly appropriate strategy for treating cancer; a disease where aberrant cellular proliferation and evasion of apoptotic signaling is mediated by the over-expression of certain characteristic protein factors [4, 5].Author: Sang Kyoon Kim, Michael B. Foote, Leaf Huang
https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201903296
Nov 11, 2019 · Overall, successful delivery of miR and chemotherapy by multifunctional nanoparticles may modulate β‐catenin/MDR/apoptosis/metastasis signaling pathways and induce programmed cancer cell death. Thus, these pH‐responsive targeting nanoparticles may provide a potential regimen for effective treatment of colorectal cancer.Author: Vivian Juang, Chih‐Hsien Chang, Chen‐Shen Wang, Hsin‐Ell Wang, Yu‐Li Lo
https://www.sciencedirect.com/science/article/abs/pii/S0196978114001314
Efficient delivery of therapeutic and diagnostic molecules to the cells and tissues is a difficult challenge. The cellular membrane is very effective in its role as a selectively permeable barrier.Author: Samad Mussa Farkhani, Alireza Valizadeh, Hadi Karami, Samane Mohammadi, Nasrin Sohrabi, Fariba Badrz...
https://www.sciencedirect.com/science/article/pii/S092777652030059X
Cancer-targeting peptides have emerged as a highly efficient approach for selective delivery of photosensitizers to cancer cells. In this study, we successfully synthesized PPC nanoparticles containing cancer targeting peptide p18-4 for improving the targeting …Author: Ye-Ji Kim, Hye-In Lee, Jin-Kyung Kim, Chun-Ho Kim, Young-Jin Kim
https://www.sciencedirect.com/science/article/pii/S0196978114001314
The plasma membrane of the cells is very effective in its role as a selectively permeable barrier. While this phospholipid bilayer is essential for cell survival and function, it also presents a major challenge for intracellular delivery of cargo such as therapeutic and diagnostic agents [47], [189].Author: Samad Mussa Farkhani, Alireza Valizadeh, Hadi Karami, Samane Mohammadi, Nasrin Sohrabi, Fariba Badrz...
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