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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302817/
Dec 18, 2018 · PD-L1 monoclonal antibody-conjugated nanoparticles enhance drug delivery level and chemotherapy efficacy in gastric cancer cells Shijie Xu , 1, * Fangbo Cui , 2, 3, * Dafu Huang , 4, * Dinghu Zhang , 5 Anqing Zhu , 6 Xia Sun , 6 Yiming Cao , 7 Sheng Ding , …Author: Shijie Xu, Fangbo Cui, Dafu Huang, Dinghu Zhang, Anqing Zhu, Xia Sun, Yiming Cao, Sheng Ding, Yao Wa...
https://www.ncbi.nlm.nih.gov/pubmed/28005451
The use of nanoparticles as delivery systems for antibodies allows for a reduction in antibody dosing and may represent a suitable alternative to increase antibody stability Areas covered: We discuss different nanocarriers intended for the delivery of antibodies as well as the corresponding encapsulation methods.Author: Flávia Sousa, Pedro Castro, Pedro Fonte, Patrick J. Kennedy, Maria Teresa Neves-Petersen, Bruno Sarm...
https://www.genengnews.com/news/what-might-be-the-best-way-to-delivery-nanoparticle-therapy-for-cancer/
Mar 26, 2020 · “Systemic exposure to either nanoparticle type induced an immune response leading to CD8 + T cell infiltration and tumor growth delay that was …
https://www.nature.com/articles/s41467-017-01830-8
Nov 23, 2017 · Delivery of free antibody and free small molecule had no effect, nor did delivery of free anti-PD-1 in combination with R848 loaded in untargeted particles, …Author: Daniela Schmid, Chun Gwon Park, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Pu...
https://www.sciencedirect.com/science/article/pii/S0168365920300547
Antibody-conjugated nanoparticles favor a safe and effective drug delivery to tumor. • Immobilization of antibodies should be well-oriented and keep biological activity. • Functionalization of nanoparticles includes covalent and non-covalent methods. • The ideal conjugation method allows a site-specific reaction and a stable coupling.Author: A.C. Marques, P.J. Costa, S. Velho, S. Velho, M.H. Amaral
https://www.sciencedirect.com/science/article/pii/S0168365916303236
The CNS has developed a series of barriers to protect itself from invading pathogens, neurotoxic molecules and circulating blood cells. These structures with diverse degrees of permeability include the blood–cerebrospinal fluid (CSF) barrier, the blood–brain barrier (BBB), the blood–retinal barrier and the blood–spinal cord barrier .Among these, the BBB is the most extensive and exclusive.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.quora.com/What-is-antibody-nanoparticle-coupling-and-what-is-its-function-in-biotechnology
Mar 19, 2015 · Antibody/nanoparticle coupling is basically attaching one to several thousands of antibody molecules onto the surface of the nanoparticles either directly or via some linker. This is a very crude representation of what it looks like, but it shoul...
https://pubs.acs.org/doi/10.1021/nn901586e
Despite recent advances in nanomaterial-based delivery systems, their applicability as carriers of cargo, especially proteins for targeting cellular components and manipulating cell function, is not well-understood. Herein, we demonstrate the ability of hydrophobic silica nanoparticles to deliver proteins, including enzymes and antibodies, to a diverse set of mammalian cells, including human ...Author: Shyam Sundhar Bale, Seok Joon Kwon, Dhiral A. Shah, Akhilesh Banerjee, Jonathan S. Dordick, Ravi S. ...
https://www.hindawi.com/journals/jnm/2009/439389/
The antibody-conjugated nanoparticles can be used principally in two biomedical applications: therapy and diagnosis. In therapy, the development of targeted drug delivery represents, together with tissue repair, the main applications of antibody-conjugated nanoparticles.Author: Manuel Arruebo, Mónica Valladares, África González-Fernández
https://www.drugtargetreview.com/article/22289/nanoparticle-mediated-enzyme-delivery-application-cancer-therapy/
Mar 09, 2017 · Enzyme therapy is a promising form of cancer treatment. The specific nature of enzyme and substrate interaction gives enzyme therapy an edge compared to standard non-specific therapies such as radiation and chemotherapy. However, since most of these enzymes are of a foreign nature, the delivery of these immunogenic enzymes has been a challenge. This study shows that enzyme …Author: Negin Mokhtari, Mukanth Vaidyanathan, Sadik Esener, Ya-San Yeh
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