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https://www.ncbi.nlm.nih.gov/pubmed/19941409
Recent advances in intravenous delivery of poorly water-soluble compounds. Shi Y(1), Porter W, Merdan T, Li LC. Author information: (1)Department R43D, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064-6196, USA.Author: Yi Shi, William Porter, Thomas Merdan, Luk Chiu Li
https://www.researchgate.net/publication/40034606_Recent_advances_in_intravenous_delivery_of_poorly_water-soluble_compounds
Recent advances in intravenous delivery of poorly water-soluble compounds. In recent years, with the widespread application of high-throughput screening technologies in drug discovery, an increasing number of new chemical entities with extremely poor aqueous solubility have been generated.
https://www.tandfonline.com/doi/abs/10.1517/17425240903307423
Aug 07, 2007 · Recent advances in intravenous delivery of poorly water-soluble compounds. In recent years, with the widespread application of high-throughput screening technologies in drug discovery, an increasing number of new chemical entities with extremely poor aqueous solubility have been generated.Author: Yi Shi, William Porter, Thomas Merdan, Luk Chiu Li
https://link.springer.com/chapter/10.1007/978-1-4614-1144-4_1
Oct 31, 2011 · Shi Y, Porter W, Merdan T, Li LC (2009) Recent advances in intravenous delivery of poorly water-soluble compounds. Expert Opin Drug Deliv 6(12):1261–1282 PubMed CrossRef Google Scholar Singla AK, Garg A, Aggarwal D (2002) Paclitaxel and its formulations.Author: Stephanie Bosselmann, Robert O. Williams
https://pdfs.semanticscholar.org/836e/45c75958d1399d6e48a10bf13665028919d9.pdf
A Study into Upper and Lower pH Limits of Intravenous Products Delivered by Infusion Koosh Patel 1, ... Recent advances in intravenous delivery of poorly water-soluble compounds. Expert Opin Drug Delivery 2009 Dec;6(12):1261-1282.
https://www.sciencedirect.com/science/article/pii/S2211383515001069
Liposomal drug delivery offer significant therapeutic benefits to poorly soluble compounds. One such example is the formulation of cyclosporine and paclitaxel in which surfactants and organic co-solvents are used for systemic administration in humans.Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.sciencedirect.com/science/article/pii/S0163782717300401
Beyond liposomes: Recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery Author links open overlay panel M.C. Teixeira a b …Author: M.C. Teixeira, C. Carbone, C. Carbone, E.B. Souto
https://www.researchgate.net/publication/318848466_Beyond_liposomes_Recent_advances_on_lipid_based_nanostructures_for_poorly_solublepoorly_permeable_drug_delivery
This paper discusses the recent advances on the use of SLN, NLC and lipid-polymer hybrid nanoparticles for the loading of lipophilic, poorly water-soluble and poorly permeable drugs, being ...
https://link.springer.com/article/10.1208/s12249-018-1007-2
May 30, 2018 · Due to the high number of poorly soluble drugs in the development pipeline, novel processes for delivery of these challenging molecules are increasingly in demand. One such emerging method is KinetiSol, which utilizes high shear to produce amorphous solid dispersions.Author: Daniel J. Ellenberger, Daniel J. Ellenberger, Dave A. Miller, Robert O. Williams
https://ijpsr.com/bft-article/solid-dispersion-overview-of-the-technology/?view=fulltext
ABSTRACT: Up to 40% of new chemical entities (NCEs) discovered today by the pharmaceutical industry through combinatorial chemistry and high through put screening are highly lipophilic or poorly water soluble compounds, so the number of such compounds has dramatically increased and the solubility behaviour of these drugs has become one of the most challenging aspects in formulation development.
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