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https://www.pdr.net/drug-summary/Merrem-meropenem-2055#:~:text=1%20g%20IV%20every%208%20hours.%20Clinical%20practice,mg%2Fkg%2Fdose%20IV%20every%208%20hours%20%28Max%3A%201%20g%2Fdose%29.
https://pubmed.ncbi.nlm.nih.gov/17867490/
To examine the clinical efficacy of antibacterial chemotherapy for life-threatening pneumonia, we investigated the clinical outcome after a prolonged infusion regimen of meropenem based on a pharmacokinetics/pharmacodynamics (PK/PD) theory. In 42 patients with severe pneumonia, the clinical efficacy …. [Clinical efficacy of prolonged (4 hour) drip infusion of meropenem against …
https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-Extended-Infusion-Meropenem.pdf
via extended infusion (4-hours) compared to standard infusion (30 mins) led to favorable clinical outcomes in febrile neutropenia patients. The subgroup analysis revealed that patients treated with meropenem alone experienced significantly shorter times to defervesence and decreased C-reactive protein values.
https://www.uspharmacist.com/article/prolongedinfusion-dosing-of-betalactam-antibiotics
Of note, meropenem has an extremely short stability of approximately 4 hours at room temperature after being mixed in solution. 22,23 Hospital pharmacies must be cognizant of this short stability and devise a workflow to ensure that the entire dose is infused within 4 hours of mixing, if prolonged infusion is used. Meropenem has the shortest stability of the antibiotics …
https://www.unmc.edu/intmed/divisions/id/asp/news/docs/meropenem_protocol-detail.pdf
meropenem against Pseudomonas isolates at different MIC values. Meropenem target attainment (Pseudomonas aeruginosa only) MIC (mg/L) Regimen/infusion time (hrs) Target %fT>MIC 0.25 0.5 1 2 4 8 16 1g q8/0.59,10 40 100 99-100 95-99 85-93 65-70 32 7 1g q8/19 40 100 99 96 86 70 37 9 1g q8/39,10 40 100 100 100 100 93-99 62 15
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096762/
Methods. We retrospectively reviewed the clinical efficacy and safety of CIs of meropenem in two Australian tertiary hospitals and assessed its stability under simulated OPAT conditions including in elastomeric infusion devices containing 1% (2.4 g) or 2% (4.8 g) concentrations at either ‘room temperature’ or ‘cooled’ conditions.
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