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https://clinicaltrials.gov/ct2/show/NCT00891423#:~:text=500mg%20of%20meropenem%20administered%20as%20a%203%20hour,minute%20infusion%2C%20in%20attaining%20target%20time%20above%20MIC.
https://pubmed.ncbi.nlm.nih.gov/25230866/
The patients in study group received intravenous 1 g of meropenem (dissolved in 40 mL saline) within 10 minutes, and followed by the remaining 750 mg by continuous intravenous infusion for 3 hours, and the treatment was repeated every 8 hours.
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-019-0622-8
Infusion doses ranging from 1500 mg to 3000 mg administered over 3 hours at eight hourly intervals were used for simulation. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) defines MIC of < 2 µg/ml as ‘sensitive’ and > 8 µg/ml as ‘resistant’ for Enterobacteriaceae, Pseudomonas aeruginosa (PsA) and Acinetobacter baumannii (AcB).
https://www.ncbi.nlm.nih.gov/sites/ppmc/articles/PMC1068632/
Comparison of the Pharmacodynamics of Meropenem in Patients with Ventilator-Associated Pneumonia following Administration by 3-Hour Infusion or Bolus Injection Sutep Jaruratanasirikul , * Somchai Sriwiriyajan , and Jarurat Punyo
https://clinicaltrials.gov/ct2/show/NCT00891423
500mg of meropenem administered as a 3 hour infusion is at least comparable to more traditional dosing of 1 g administered as a 30 minute infusion, in attaining target time above MIC. We plan to compare standard meropenem therapy (1g over 30 minute infusion) with prolonged infusion meropenem (500mg over 3 hour infusion) in a general intensive care unit.
https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-Extended-Infusion-Meropenem.pdf
Meropenem Extended-Infusion (3-hour infusion) Creatinine Clearance >50 mL/min 26-50 mL/min 10-25 mL/min <10 mL/min, HD CRRT General (FN, PNA, Pseudomonas) 1g q8h 1g Q12h 500 mg q12h 500mg Q24h . Dose after HD on HD days. 1g q8-12h . Meningitis, CF . 2g Q8H 2g Q12h 1g Q12H 1g q24h . Dose after HD on HD days. 2g q12h . Abbreviations:
https://pubmed.ncbi.nlm.nih.gov/29954243/
In this retrospective study, we compared intensive care unit (ICU) mortality and clinical response in patients who received meropenem for ≥72 hours administered per EIM protocol of 1 g over 3 hours every 8 hours versus intermittent infusion (IIM) protocol of 500 mg over 30 minutes every 6 hours.
https://einsteinmed.edu/uploadedFiles/departments/medicine/Divisions/infectious-diseases/Antimicrobial_Stewardship_Program/Extended%20Infusion%20Zosyn%20Cefepime%20Meropenem.pdf
Meropenem extended infusion (over 3-hr) will be recommended by ID consult service for selected patient cases, therefore, time of infusion 30- min and 3-hr infusion will be available for clinician to order.
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