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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623511/
Jul 31, 2012 · Current mucosal vaccine adjuvants and vaccine delivery systems under clinical application or preclinical researches Bacterial toxins and derivatives The most widely experimentally used mucosal adjuvants in animals are cholera toxin (CT) and closely related Escherichia coli heat labile enterotoxin (LT), and their mutants and subunits.Author: Joon Haeng Rhee, Shee Eun Lee, Soo Young Kim
https://www.ncbi.nlm.nih.gov/pubmed/22524387
Efforts have focused on efficient delivery of vaccine antigens to mucosal sites that facilitate uptake by local antigen-presenting cells to generate protective mucosal immune responses. Discovery of safe and effective mucosal adjuvants are also being sought to enhance the magnitude and quality of the protective immune response.Author: Kim A. Woodrow, Kaila M. Bennett, David D. Lo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027714/
May 09, 2016 · It is worthy to note that some mucosal adjuvants are both immunostimulators and delivery systems, such as chitosan and its derivatives. 1 After decades of research, it has been proved that mucosal adjuvants can induce protective local and systemic immune responses, which is essential for effective mucosal vaccinations against a series of infectious diseases. 2-5 Furthermore, mucosal adjuvants …Author: Lingbin Zeng
https://www.ncbi.nlm.nih.gov/pubmed/25630573
This is due to various challenges associated with the development of an effective mucosal vaccine that can work against a variety of infections, and various problems concerned with the safe delivery of developed vaccine. For instance, protein antigen alone is not just sufficient enough for the optimal delivery of antigen(s) mucosally.Author: Atul Srivastava, Devegowda Vishakante Gowda, SubbaRao V. Madhunapantula, Chetan G. Shinde, Meenakshi...
https://www.sciencedirect.com/science/article/pii/S0378517319307768
Mucosal vaccines based on biodegradable nanoparticles as vaccine adjuvants and delivery systems have attracted much attention in the formulation of mucosal vaccines because vaccines prepared from biodegradable polymer nanoparticles as vaccine adjuvants and delivery vehicles can significantly improve humoral, cellular and mucosal immune responses, and may also sustainably release antigen slowly …Author: Zheng Jin, Shuang Gao, Xianlan Cui, Dejun Sun, Kai Zhao
https://www.ncbi.nlm.nih.gov/pubmed/28630108
Jul 01, 2017 · Mucosal or epicutaneous delivery of vaccines helps target the inductive sites for SIgA responses. The efficacy of such vaccines relies on the identification and/or engineering of vaccine adjuvants capable of supporting the development of SIgA alongside systemic immunity and delivery systems that improve vaccine delivery to the targeted anatomic sites and immune cells.Author: Prosper N. Boyaka
https://www.sciencedirect.com/science/article/pii/S0169409X06000068
The delivery of vaccines through the mucosal route is very practical, non-invasive and efficacious for the induction of mucosal and systemic immune responses. Appropriately formulated mucosal vaccines can stimulate all arms of the immune system and could be exploited for protection against pathogens that infect the host through the mucosal surfaces as well as those acquired through other routes.Author: Maria Teresa De Magistris
https://www.hindawi.com/journals/jir/2019/8303648/
An effective immunization using oral vaccines is achieved when sufficient quantities of antigen are transported across the mucosal barrier by M cells into Peyer’s patches and subsequently presented to T cells by antigen-presenting cells (APCs) [11].Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
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