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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/
Mucoadhesive drug delivery systems prolong the residence time of the dosage form at the site of application or absorption. They facilitate an intimate contact of the dosage form with the underlying absorption surface and thus improve the therapeutic performance of the drug.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/
Mucoadhesive drug delivery systems in the past have been formulated as powders, compacts, sprays, semisolids, or films. For example, compacts have been used for drug delivery to the oral cavity,[ 51 ] and powders and nanoparticles have been used to facilitate drug administration to the nasal mucosa.[ 52 , 53 ] Recently oral strips[ 54 ] were developed for tongue or buccal cavity.
https://www.sciencedirect.com/science/article/pii/S1740674905000065
Mucoadhesive systems in oral drug delivery promise the advantage of a prolonged gastric or small intestinal residence time, an intimate contact of the delivery system with the absorption membrane and the basis for interactions of multifunctional polymers with the mucosa such as permeation enhancement or enzyme inhibition.Author: Andreas Bernkop-Schnürch
https://www.researchgate.net/publication/221750117_Mucoadhesive_drug_delivery_system_An_overview
Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of...
http://www.jbr-pub.org.cn/article/doi/10.7555/JBR.27.20120136
Starting with a brief introduction of the mucoadhesive drug delivery systems, oral mucosa, and the theories of mucoadhesion, this article then proceeds to cover the works done so far in the field of MBDDS, categorizing them on the basis of ailments they are meant to cure.Author: Ritu M Gilhotra, Mohd Ikram, Sunny Srivastava, Neeraj Gilhotra
https://www.sciencedirect.com/science/article/pii/S0939641115004531
Mucoadhesive drug delivery possesses the advantages for vaginal delivery by prolonging drug residence time at the site of absorption, and thus less frequent application of the dosage form , , . Apart from mucoadhesive particulate delivery system, mucopenetrating strategy also showed potential in drug delivery through vaginal fluid in vivo [101] .Author: Kesinee Netsomboon, Andreas Bernkop-Schnürch
https://pharma.unibas.ch/de/research/research-groups/pharmaceutical-technology-2253/research/drug-delivery/
Mucoadhesive drug-loaded microparticles for colon drug delivery and local therapy This research aims to develop an oral drug delivery system for targeted and sustained colonic release to facilitate the treatment of colonic diseases, such as ulcerative colitis, Crohn’s disease, or colon cancer.
https://www.slideshare.net/MUHEEM_007/mucoadhesive-drug-delivery-system
Feb 24, 2013 · The mucosa is well supplied with both vascular and lymphatic drainage. Mucoadhesive drug delivery is a promising area for systemic delivery of orally inefficient drugs as well as an attractive alternative for noninvasive delivery of potent peptide and perhaps protein drug molecules. A rational approach to dosage form design requires a complete understanding of the physicochemical and biopharmaceutical properties of the drug …
http://doktori.bibl.u-szeged.hu/2828/19/ThesisHorvatGabriella.pdf
matrices which exhibit strong mucoadhesion are promising platforms in ocular drug delivery from the aspect of improved bioavailability. In my Ph.D. work, first (hyaluronic acid (HA) derivatives) and second generation (thiolated polymers) mucoadhesive polymers were characterized as potential ocular drug delivery systems.
http://doktori.bibl.u-szeged.hu/4048/1/Disszertacio_Mihaly_Gottnek_2017_Szeged.pdf
However, mucoadhesive films applied to the oral mucosa eliminate these problems, and not only local effects (treatment of aphthous ulcer, gum inflammation or toothache), but also system wide effects (management of pain and angina pectoris etc.) can be achieved. Their main advantages are sustained drug delivery and chronic systemic therapy.
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