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https://www.researchgate.net/publication/263725289_Mucoadhesive_Drug_Delivery_Systems_for_Nose-to-Brain_Targeting_of_Dopamine
Request PDF Mucoadhesive Drug Delivery Systems for Nose-to-Brain Targeting of Dopamine Drugs can be transported directly from the nasal cavity to the central nervous system via olfactory ...
https://www.ingentaconnect.com/content/asp/jonn/2012/00000002/00000001/art00005
Apr 01, 2012 · Drugs can be transported directly from the nasal cavity to the central nervous system via olfactory epithelium thereby bypassing blood-brain-barrier and blood-cerebrospinal fluid barrier. The brain uptake requires nasal formulations and device capable to provide olfactory region deposition, appropriate site permanence and favorable amounts of drug for transport.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409749/
Feb 17, 2019 · The nasal administration of drugs using the nose-to-brain pathway allows direct drug targeting into the brain, avoiding the first-pass effect and bypassing the BBB. Through the nasal route, the drug can access the brain directly along the trigeminal and olfactory nerves, which are located in the upper part of the nasal cavity.Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://www.sciencedirect.com/science/article/pii/S1773224717305981
Nano-carrier enabled drug delivery systems for nose to brain targeting for the treatment of neurodegenerative disorders Author links open overlay panel Shadab Md a Subrat K. Bhattmisra b Farrukh Zeeshan a Naiyer Shahzad c Md Ali Mujtaba d Venkata Srikanth Meka a Ammu Radhakrishnan e Prashant Kesharwani a Sanjula Baboota f Javed Ali fAuthor: Shadab, Subrat K. Bhattmisra, Farrukh Zeeshan, Naiyer Shahzad, Ali Mujtaba, Venkata Srikanth Meka, A...
https://www.sciencedirect.com/science/article/pii/B9780128177785000099
Due to such disadvantages, novel carrier systems are used for nose-to-brain delivery, which circumvents the boundaries and increases drug targeting to the brain. This chapter briefly discusses some common CNS disorders, present therapies, and challenges to brain drug delivery [11] .Author: Amit Alexander, Mukta Agrawal, Mahavir Bhupal Chougule, Shailendra Saraf, Swarnlata Saraf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255357/
The application of mucoadhesive polymers in nasal drug delivery systems has gained to promote dosage form residence time in the nasal cavity as well as improving intimacy of contact with absorptive membranes of the biological system. The various new technology uses in development of nasal drug delivery dosage forms are discussed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/
Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT.
https://www.sciencedirect.com/science/article/pii/S1773224716301307
3. Delivery devices for enhanced nose to brain drug delivery. Successful targeting of nose-to-brain drug delivery requires formulation to be administered in such a way that the amount deposited on the olfactory epithelium is maximized.Author: Zachary N. Warnken, Hugh D C Smyth, Alan B. Watts, Steven D Weitman, John G. Kuhn, Robert O. William...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/
Vaginal Mucoadhesive Drug Delivery Systems. The vagina is a fibrovascular tube connecting the uterus to the outer surface of the body. The vaginal epithelium consists of a stratified squamous epithelium and lamina propia. Dosage forms used for vaginal route are solutions, gels, suspensions, suppositories, creams,...
https://www.researchgate.net/publication/234044763_Nose_to_Brain_Targeted_Drug_Delivery_bypassing_the_Blood-Brain_Barrier_An_overview
This chapter discusses the scientific developments of nose-to-brain delivery of drugs in the past 10 years and the use of novel delivery systems and devices for optimization of the amount of drug ...
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