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https://www.pnas.org/content/115/42/E9944
Oct 16, 2018 · Nanoparticle-mediated delivery of siRNA to hepatocytes has treated disease in humans. However, systemically delivering RNA drugs to nonliver tissues remains an important challenge. To increase the number of nanoparticles that could be studied in vivo, we designed a high-throughput method to measure how >100 nanoparticles delivered mRNA that was translated into functional …Author: Cory D. Sago, Melissa P. Lokugamage, Kalina Paunovska, Daryll A. Vanover, Christopher M. Monaco, Nir...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443240/
3.2 . Polymer-based nanoparticles for mRNA delivery. Polymeric nanoparticles are another class of nanoscale platforms for mRNA delivery. Previously, a wide variety of polymers were designed and synthesized including polyamines, polypeptides, diblock polymers, and triblock polymers.Author: Bin Li, Xinfu Zhang, Yizhou Dong
https://www.nature.com/articles/s41598-018-36910-2
Jan 24, 2019 · Specific LNP formulations can be internalized by platelets. The amount of mRNA delivered to platelets by four different classes of lipid nanoparticles (LNPs) was …Author: S. Novakowski, K. Jiang, G. Prakash, C. Kastrup
https://www.acs.org/content/acs/en/acs-webinars/drug-discovery/lipid-nanoparticles.html
A Nanomedicine Overview for mRNA Delivery: Innovative Methods Using Lipid Nanoparticles ; A Nanomedicine Overview for mRNA Delivery: Innovative Methods Using Lipid Nanoparticles. March 29, 2018 @ 2-3pm ET Session 3 of the 2018 Drug Design and Delivery Symposium. ... Why use of lipid nanoparticles for RNA delivery;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059071/
Induction of protein synthesis by the external delivery of in-vitro transcription-messenger RNA (IVT-mRNA) has been a useful approach in the realm of cell biology, disease treatment, reprogramming of cells, and vaccine design. Therefore, the development of new formulations for protection of mRNA against nucleases is required to maintain its activity in-vivo.
https://www.nature.com/articles/s41467-020-14527-2
Feb 20, 2020 · Endosomal sequestration of lipid-based nanoparticles is a barrier to delivery of nucleic acids. Here the authors test an array of cholesterol variants and perform in-depth investigation of ...Author: Siddharth Patel, N. Ashwanikumar, Ema Robinson, Yan Xia, Cosmin Mihai, Joseph P. Griffith, Shangguo ...
https://www.sciencedirect.com/science/article/pii/S2452199X20300414
Lipid-like nanoparticles (LLNs) have been extensively explored for messenger RNA (mRNA) delivery in various biomedical applications. However, the long-term storage of these nanoparticles is still a challenge for their clinical translation.
https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.6b03329
The intracellular delivery of mRNA vaccines to the cytosol of antigen presenting immune cells is still not sufficiently well understood. Here, we report on the development of a lipid nanoparticle formulation for the delivery of mRNA vaccines to induce a cytotoxic CD 8 T cell response. ... Cationic lipid-assisted nanoparticles for delivery of ...Author: Matthias A. Oberli, Andreas M. Reichmuth, J. Robert Dorkin, Michael J. Mitchell, Owen S. Fenton, Ana...
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b02917
mRNA therapeutics hold great potential for treating a variety of diseases through protein-replacement, immunomodulation, and gene editing. However, much like siRNA therapy the majority of progress in mRNA delivery has been confined to the liver. Previously, we demonstrated that poly(β-amino esters), a class of degradable polymers, are capable of systemic mRNA delivery to the lungs in mice ...Author: James C. Kaczmarek, Kevin J. Kauffman, Owen S. Fenton, Kaitlyn Sadtler, Asha K. Patel, Michael W. He...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30017-4
mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to fully realizing the potential of mRNA vaccines. Pre-clinical and clinical studies have demonstrated that mRNA delivered intramuscularly (IM) with first-generation lipid nanoparticles (LNPs ...Author: Kimberly J. Hassett, Kerry E. Benenato, Eric Jacquinet, Aisha Lee, Angela Woods, Olga Yuzhakov, Sunn...
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