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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653240/
Apr 08, 2013 · Intranasal delivery to the CNS is an especially useful technique because not only is it rapid, but it targets the CNS reducing systemic exposure. For example, intranasal administration of deferoxamine to rats resulted in 3-19 times higher concentrations in brain regions with 28 times lower concentrations in the blood 11.Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://www.jove.com/video/4440/intranasal-administration-of-cns-therapeutics-to-awake-mice
Figure 1. Photos of different stages and angles of holding a mouse for awake intranasal delivery of drug. 1A) Hold the mouse down firmly on the cage top with the dominant hand leaving the shoulders exposed to grip the skin. 1B) Use the thumb and middle finger of the non-dominant hand to grip and pull up skin just behind the shoulder blades.Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://www.researchgate.net/post/Dear_colleagues_please_tell_us_how_to_do_intranasal_administration_to_mice_methodHow_to_minimize_animal_stress
Dear colleagues, please tell us how to do intranasal administration to mice (method)?How to minimize animal stress? ... 2ul for delivery to the upper airway, and 20ul for delivery to the lower ...
https://www.youtube.com/watch?v=u2F6UU0dQw0
Jan 27, 2015 · A Wicked Harpoon Eyed Spring Loaded Mouse Trap From The Civil War Era. Mousetrap Monday - Duration: 11:08. Shawn Woods Recommended for you. NewAuthor: Dilini Ranatunga
https://www.youtube.com/watch?v=ny_MVCnkLRc
Jun 30, 2016 · "The truth about mobile phone and wireless radiation" -- Dr Devra Davis - Duration: 1:01:30. The University of Melbourne Recommended for you
https://www.sciencedirect.com/science/article/pii/S0361923018303678
Mouse and rat models are very useful for preliminary studies of nose-to-brain drug absorption, while rabbit, dog and sheep models are more frequently used for pharmacokinetic studies. ... Intranasal delivery of recombinant human VEGF also reduced infarct volume, improved behavioral recovery, and enhanced angiogenesis following MCAO (Xu et al ...Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.jove.com/video/55845/intranasal-delivery-therapeutic-stem-cells-to-glioblastoma-mouse
Stem cells are promising therapeutic carriers to treat brain tumors due to their intrinsic tumor tropism. Non-invasive intranasal stem cell delivery bypasses the blood brain barrier and demonstrates strong potential for clinical translation. This article summarizes the basic principles of intranasal stem cell delivery in a mouse …Author: Dou Yu, Gina Li, Maciej S. Lesniak, Irina V. Balyasnikova
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286442/
Feb 24, 2012 · Intranasal instillation is a widely used procedure for pneumonic delivery of drugs, vaccine candidates, or infectious agents into the respiratory tract of research mice. However, there is a paucity of published literature describing the efficiency of this delivery technique.Author: Mark A. Miller, Jennifer M. Stabenow, Jyothi Parvathareddy, Andrew J. Wodowski, Thomas P. Fabrizio, ...
https://journals.physiology.org/doi/pdf/10.1152/ajplung.00173.2001
the mouse during intranasal delivery has also varied between studies, with horizontal (13) and head-down supine (12) positions having been used. The specific delivery protocols used in these studies are thought to influence the relative distribution of the delivered sub …
https://www.sciencedirect.com/science/article/pii/S0168365916301079
Particulate delivery systems are proven efficient carriers for vaccine delivery , and the most frequently used systems are lipoplex , and liposomes , , , . While these lipid-based nano carriers can deliver mRNA efficiently, the epithelial barrier remains a challenge to intranasal delivery of mRNA vaccines.Author: Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun
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