We have collected information about Morpholino Delivery for you. Follow the links to find out details on Morpholino Delivery.
https://www.gene-tools.com/morpholino_antisense_oligos
When using a fluorescent Morpholino to confirm delivery, start with a concentration of 10 microMolar Morpholino oligo in the culture medium. This is a high enough concentration that after 16 hours the fluorescent-tagged Morpholino should be visible in the cytosol by fluorescence microscopy.
https://www.gene-tools.com/delivery_products
For delivering unmodified or fluorescent-tagged Morpholino oligos into cultured cells, Gene Tools makes Endo-Porter delivery reagent and resells Sarstedt cell scrapers. Gene Tools also provides protocols for making Special Delivery heteroduplex oligos and provides EPEI delivery reagent to release the heteroduplexes from endosomes.
https://www.future-science.com/doi/10.2144/000113005
May 16, 2018 · Systemic delivery of Vivo-Morpholino in transgenic mice. To test the delivery efficiency of Vivo-Morpholino in animal models, we used a strain of transgenic mice developed by Ryszard Kole and co-workers which bear a human β-globin intron fused with the green fluorescent protein (GFP) gene . The GFP pre-mRNA is ubiquitously expressed and ...Author: Paul A. Morcos, Yongfu Li, Shan Jiang
https://store.gene-tools.com/system/files/msds/other-tools/Endo-PorterJun2018.pdf
ENDO-PORTER DELIVERY OF MORPHOLINO OLIGOS 14 June 2018 I. INTRODUCTION Endo-Porter is a reagent for delivering Morpholino oligos, peptides or proteins into the cytosol of cultured cells. Endo-Porter is a peptide-based reagent which enters cells by endocytosis, works in the presence of 10% serum, and allows delivery ofFile Size: 94KB
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992344/
Jun 01, 2018 · In this study, we investigated a few saponins for their potential to improve delivery performance of an antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in vivo. The results showed that these saponins, especially digitonin and tomatine, improve the delivery efficiency of PMO comparable to Endo-Porter-mediated PMO ...Author: Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan Lu, Qilong Lu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376484/
Apr 01, 2015 · Common delivery systems for ON therapeutics. The most common methods to increase cellular uptake of therapeutic ONs are based on cationic polymers, liposomes, or similar nanoparticle delivery systems [].One such system involves cationic peptide delivery vehicles, often referred to as cell-penetrating peptides (CPPs) or peptide transduction domains [].Author: Peter Järver, Eman M. Zaghloul, Andrey A. Arzumanov, Amer F. Saleh, Graham McClorey, Suzan M. Hammon...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30096-4
Jun 07, 2019 · However, therapeutic applications of AOs remain limited, particularly because of the lack of efficient cellular delivery methods imperative for achieving efficacy. In this study, we investigated a few aminoglycosides (AGs) for their potential to improve the delivery of antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in ...Author: Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan Lu, Qilong Lu
https://www.nature.com/articles/nm1345
Jan 29, 2006 · Systemic delivery of morpholino antisense oligonucleotide restores dystrophin expression bodywide to functional levels and improves dystrophic pathology. (PDF 1508 kb) Supplementary Fig. 4.Author: Julia Alter, Fang Lou, Adam Rabinowitz, HaiFang Yin, Jeffrey Rosenfeld, Steve D Wilton, Terence A Pa...
https://www.nature.com/articles/s41467-017-00924-7
Oct 16, 2017 · Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle. James S. Novak 1,2,3, Marshall W. Hogarth 1, …Author: James S. Novak, Marshall W. Hogarth, Jessica F. Boehler, Marie Nearing, Maria C. Vila, Raul Heredia,...
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