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https://www.sciencedirect.com/science/article/pii/S0142961206000056
The aim of this study is to develop a non-viral vector for gene delivery system. Montmorillonite (MMT) is one of clay minerals that consist of hydrated aluminum with Si–O tetrahedrons on the bottom of the layer and Al–O(OH) 2 octahedrons on the top. The inter-layer space is about 12 Å. The room is not enough to accommodate DNA for gene delivery.Author: Feng-Huei Lin, Chia-Hao Chen, Winston T.K. Cheng, Tzang-Fu Kuo
https://www.ncbi.nlm.nih.gov/pubmed/16488006
Modified montmorillonite as vector for gene delivery. Lin FH(1), Chen CH, Cheng WT, Kuo TF. Author information: (1)Institute of Biomedical Engineering, National Taiwan University, and National Taiwan University Veternary Hospital, Taipei, Taiwan. Currently, gene delivery systems can be divided into two parts: viral or non-viral vectors.Author: Feng-Huei Lin, Chia-Hao Chen, Winston T.K. Cheng, Tzang-Fu Kuo
https://www.researchgate.net/publication/7289173_Modified_montmorillonite_as_vector_for_gene_delivery
The aim of this study is to develop a non-viral vector for gene delivery system. Montmorillonite (MMT) is one of clay minerals that consist of hydrated aluminum with Si-O tetrahedrons on the ...
https://www.deepdyve.com/lp/elsevier/modified-montmorillonite-as-vector-for-gene-delivery-B7y3098Bib
Jun 01, 2006 · Modified montmorillonite as vector for gene delivery In general, viral vectors have a higher efficiency on gene delivery. However, they may sometimes provoke mutagenesis and carcinogenesis once re-activating in human body.
https://bpb.pharm.or.jp/bpb/200412/b12_2049.pdf
Montmorillonite, a bioinert clay mineral, was examined as a novel vector for an oral gene-delivery system. The complex of montmorillonite and plasmid DNA encoding the enhanced green fluorescent protein (EGFP) gene was prepared at various weight ratios, and then transfected into cultured intestinal epithelial cells (IEC-6) in vitro. The EGFP ...
https://www.sciencedirect.com/science/article/pii/B9780128137413000285
The montmorillonite (MT) clay is recently a current topic to study its utilization as additive and drug carrier material at the research level. Bentonite is a major part of MT which has already been approved as an excipient. These nano clay composites appeal their use in various dosing form, mainly for controlled release of the drug.Author: Sufia ul Haque, Abu Nasar, Inamuddin
https://www.researchgate.net/publication/8150907_Protective_Effect_of_Montmorillonite_on_Plasmid_DNA_in_Oral_Gene_Delivery_into_Small_Intestine
Montmorillonite, a bioinert clay mineral, was examined as a novel vector for an oral gene-delivery system. The complex of montmorillonite and plasmid DNA encoding the enhanced green fluorescent ...
https://en.wikipedia.org/wiki/Vectors_in_gene_therapy
For example, the most popular retroviral vector for use in gene therapy trials has been the lentivirus Simian immunodeficiency virus coated with the envelope proteins, G-protein, from Vesicular stomatitis virus. This vector is referred to as VSV G-pseudotyped lentivirus, and infects an almost universal set of cells. This tropism is characteristic of the VSV G-protein with which this vector is coated.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753741/
An innovative chitosan-derivative-modified montmorillonite (HTCC-modified montmorillonite) with an excellent biocompatibility, cell growth, and antibacterial efficiency for tissue engineering applications was synthesized and evaluated in the terms of biological and microbiological activities.Author: Majid Aliabadi, Roya Dastjerdi, Kourosh Kabiri
https://pubs.rsc.org/en/content/articlelanding/2018/bm/c8bm00672e#!
Previously, our group carried out a series of studies using branched polyethyleneimine with 25 000 g mol −1 molar mass (bPEI-25k) as a gene delivery vector and came up with the theory that free cationic chains un-complexed with plasmid DNA (pDNA) can greatly increase the gene transfection efficiency and influence the intracellular delivery process.
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