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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · Cell-Specific Aptamer-Mediated Targeted Drug Delivery Jiehua Zhou 1 and John J. Rossi 1,, 2 1 Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California.Author: Jiehua Zhou, John J. Rossi
https://www.liebertpub.com/doi/abs/10.1089/oli.2010.0264
Feb 17, 2011 · Cell-Specific Aptamer-Mediated Targeted Drug Delivery. Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California. Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California.Author: Jiehua Zhou, John J. Rossi
https://www.researchgate.net/publication/49706257_Cell-Specific_Aptamer-Mediated_Targeted_Drug_Delivery
Such aptamer-mediated delivery systems are expected to achieve selective uptake into target cells, thereby minimizing unwanted side effects of the drugs in nontarget cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
The perfect target for aptamer-mediated delivery is one that is highly expressed on all target cells, is efficiently internalized, and is not expressed on the surface of non-target cells. Although a perfect target may not exist, several aptamers against excellent targets have been identified.Author: Partha Ray, Rebekah R. White
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30309-2
Jan 01, 2014 · The two main strategies for targeted delivery using cell-specific aptamers are: (i) aptamer-drug conjugates, in which aptamer is directly conjugated to the drug molecules via either a connector or a physical intercalation, and (ii) the aptamer-nanomaterials system, in which the aptamer is decorated on the surface of nanocarriers for targeted drug delivery.Author: Jiehua Zhou, John J. Rossi
https://www.nature.com/articles/srep07851
Jan 19, 2015 · AS1411, binding to the receptor nucleolin on the cancer cell surface with high affinity and selectivity, was used to modify the UCNPs@MOF NCs with the capability of targeted biological imaging. By grafting AS1411 aptamers upon UCNPs@MOF NCs, target-specific drug delivery …Author: Kerong Deng, Zhiyao Hou, Xuejiao Li, Chunxia Li, Yuanxin Zhang, Xiaoran Deng, Ziyong Cheng, Jun Lin
http://www.eurekaselect.com/143383/article
Targeted drug delivery is a smart evolution essential to address major challenges associated with conventional drug delivery systems. These challenges mostly result in poor pharmacokinetics due to the inability of the active pharmaceutical ingredients to specifically act on malignant cells thus, causing poor therapeutic index and toxicity to surrounding normal cells.Author: Kei Xian Tan, Michael K. Danquah, Amandeep Sidhu, Lau Sie Yon, Clarence M. Ongkudon
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30169-X
Successful drug delivery via a targeted approach must meet additional requirements regarding the stability of the drug complex–drug must be retained in the complex during targeting which may take several hours, but released from the complex after binding to the targeted cell. Drug delivery should also be efficient, releasing multiple drugs ...Author: Olcay Boyacioglu, Christopher H Stuart, George Kulik, William H Gmeiner
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · In addition, many aptamers are internalized upon binding to cellular receptors, making them useful targeted delivery agents for small interfering RNAs (siRNAs), microRNAs and conventional drugs.Author: Jiehua Zhou, John Rossi
https://www.researchgate.net/publication/307895794_Aptamer_Mediated_Niosomal_Drug_Delivery
Moreover, the specificity of cellular targeting of niosomal drug delivery systems can be further improved by active targeting for tumor therapy, by using a ligand coupled to the surface of niosomes...
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