Mitochondrial Copper Metabolism And Delivery To Cytochrome C Oxidase

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Mitochondrial Copper Metabolism and Delivery to Cytochrome ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864105/
    CYTOCHROME C OXIDASE: A MITOCHONDRIAL COPPER/HEME METALLOENZYME. Aerobic life depends on cellular copper homeostasis and distribution since this element is a critical component of enzymes involved in primary metabolism ().Copper ions can undergo unique chemistry due to their ability to adopt distinct redox states, either oxidized [Cu(II)] or reduced [Cu(I)], and they serve as important ...Author: Darryl Horn, Antonio Barrientos

Mitochondrial copper metabolism and delivery to cytochrome ...

    http://onlinelibrary.wiley.com/doi/10.1002/iub.50/full
    Here we will focus on describing the pathways involved in the delivery of copper to cytochrome c oxidase (COX), a mitochondrial metalloenzyme acting as the terminal enzyme of the mitochondrial respiratory chain. The catalytic core of COX is formed by three mitochondrially-encoded …

Mitochondrial copper metabolism and delivery to cytochrome ...

    https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.50
    CYTOCHROME C OXIDASE: A MITOCHONDRIAL COPPER/HEME METALLOENZYME . Aerobic life depends on cellular copper homeostasis and distribution since this element is a critical component of enzymes involved in primary metabolism ().Copper ions can undergo unique chemistry because of their ability to adopt distinct redox states, either oxidized [Cu(II)] or reduced [Cu(I)], and they serve as …Author: Darryl Horn, Antonio Barrientos

Mitochondrial Copper Metabolism and Delivery to Cytochrome ...

    https://www.researchgate.net/publication/5394153_Mitochondrial_Copper_Metabolism_and_Delivery_to_Cytochrome_c_Oxidase
    Mitochondrial copper homeostasis and delivery to cytochrome c oxidase appears to require the function of a growing number of gene products, some of them largely uncharacterized, listed in Table 1 ...

Mitochondrial copper metabolism and delivery to cytochrome ...

    https://miami.pure.elsevier.com/en/publications/mitochondrial-copper-metabolism-and-delivery-to-cytochrome-c-oxid
    Dec 01, 2008 · title = "Mitochondrial copper metabolism and delivery to cytochrome C oxidase", abstract = "Metals are essential elements of all living organisms. Among them, copper is required for a multiplicity of functions including mitochondrial oxidative phosphorylation and protection against oxidative stress.Author: Darryl Horn, Antonio Barrientos

Mitochondrial copper metabolism and delivery to cytochrome ...

    https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/iub.50
    Here we will focus on describing the pathways involved in the delivery of copper to cytochrome c oxidase (COX), a mitochondrial metalloenzyme acting as the terminal enzyme of the mitochondrial respiratory chain. The catalytic core of COX is formed by three mitochondrially‐encoded subunits …Author: Darryl Horn, Antonio Barrientos

Mitochondrial Cytochrome c Oxidase Biogenesis: Recent ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842095/
    Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen consumption and is essential for aerobic energy generation in the form of ATP. Human COX is a copper-heme A hetero-multimeric complex formed by 3 catalytic core subunits encoded in the mitochondrial DNA and 11 subunits encoded in the nuclear genome.Author: Alba Timón-Gómez, Eva Nývltová, Luciano A. Abriata, Alejandro J. Vila, Jonathan Hosler, Antonio Barr...

COA6 Is Structurally Tuned to Function as a Thiol ...

    https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31536-0
    Soma et al. reports the solution structure of cytochrome c oxidase assembly factor COA6 and establishes that it functions as a thiol-disulfide oxidoreductase in a relay system that delivers copper to COX2, a copper-containing subunit of the mitochondrial cytochrome c oxidase.Author: Shivatheja Soma, Marcos N. Morgada, Mandar T. Naik, Aren Boulet, Anna A. Roesler, Nathaniel Dziuba, ...

Mitochondrial copper metabolism in yeast: interaction ...

    https://www.sciencedirect.com/science/article/pii/S0014579300021761
    Yeast mitochondrial Sco1p is required for the formation of a functional cytochrome c oxidase (COX). It was suggested that Sco1p aids copper delivery to the catalytic center of COX. Here we show by affinity chromatography and coimmunoprecipitation that Sco1p interacts with subunit Cox2p.Author: Anja Lode, Margret Kuschel, Claudia Paret, Gerhard Rödel

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