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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · Mounting evidence suggests that miRNA-based therapies, either restoring or repressing miRNAs expression and activity, hold great promise. However, despite the early promise and exciting potential, critical hurdles often involving delivery of miRNA-targeting agents remain to be overcome before transition to clinical applications.Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
In vivo miRNA delivery strategies for cancer therapy. A lot of work has been done in exploiting and evaluating the features of tumor and tumor microenvironment to improve RNA delivery. There are two classes of strategies for miRNA delivery — local and systemic delivery.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S0169409X17303149
miRNA delivery for skin wound healing ... Utilization of miRNAs presents an attractive proposition for the development of genetic therapeutics for wound healing. miRNA-based therapeutics show unique advantages because by modulating a single miRNA, a group of functionally related genes in a pathway can be targeted, which is extremely effective ...Author: Zhao Meng, Dezhong Zhou, Yongsheng Gao, Ming Zeng, Wenxin Wang
https://www.nature.com/articles/s41551-017-0157-y
Nov 27, 2017 · An injectable hyaluronic acid hydrogel for the sustained delivery of miR-302 mimics to the heart promotes cardiomyocyte proliferation and improves cardiac function in …Author: Leo L. Wang, Ying Liu, Jennifer J. Chung, Tao Wang, Ann C. Gaffey, Minmin Lu, Christina A. Cavanaugh...
https://www.genengnews.com/magazine/153/mirna-rnai-delivery-and-applications/
Mar 01, 2011 · For our current studies and from a convenience perspective, we use lipid-based transfection methods to delivery miRNA/siRNAs into cultured cells. It is convenient because it …
https://www.sciencedirect.com/science/article/pii/S0169409X14001033
In vivo miRNA delivery strategies for cancer therapy. A lot of work has been done in exploiting and evaluating the features of tumor and tumor microenvironment to improve RNA delivery. There are two classes of strategies for miRNA delivery — local and systemic delivery. 7.1. Local delivery of miRNAsAuthor: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.hindawi.com/journals/ije/2019/6782653/
5.2.3. Other Nonviral miRNA Delivery Systems. Liu et al. fabricated a nonviral miRNA delivery method based on nanocapsules, which are neutrally charged and size-homogeneous with enhanced miRNA stability and high transfection efficiency and can release the miRNAs once inside cells. The nanocapsules were synthesized by in situ polymerization.Author: Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo
https://www.researchgate.net/publication/321929807_MiRNA_delivery_for_skin_wound_healing
Meanwhile, non-viral miRNA delivery systems, such as cationic polymers, peptides, and liposomes, are recognized by their lower toxicity, water solubility, and resistance to endonucleases or ...
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