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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · Takeshita F, Patrawala L, et al. Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Molecular therapy : the journal of the American Society of Gene Therapy. 2010; 18:181–187. [PMC free article]Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://www.sciencedirect.com/science/article/pii/S0168365913008031
1. Discovery and action of miRNAs. MicroRNAs (miRNAs) are one of a growing number of non-coding RNA molecules that act within a cell , .Noncoding RNAs include miRNA, small interfering RNA (siRNA), ribozymes, among others .Both miRNA and siRNA interact with messenger RNA (mRNA), typically marking the mRNA for degradation as will be described in this review.Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://visualsonline.cancer.gov/details.cfm?imageid=10529
MicroRNA Delivery: Description: MicroRNAs (miRNAs) are small molecules critical to gene expression. Researchers are creating artificial miRNAs capable of binding to, and silencing, genes associated with cancer. Delivering such miRNAs to their target is another challenge.
https://www.sciencedirect.com/science/article/pii/S0734975017300204
2.4. Challenges in microRNA delivery. Similar to other therapeutic oligonucleotides, miRNA delivery is a major challenge because naked miRNAs are quickly degraded by nucleases and cleared via renal excretion. Moreover, RNA administration may induce innate immune responses, leading to …Author: I. Fernandez-Piñeiro, I. Badiola, A. Sanchez
https://www.nature.com/articles/ncomms12868
Sep 19, 2016 · An in vivo experiment showed that the use of nanoparticles embedded in a hydrogel scaffold as a miRNA delivery vehicle enables an efficient …Author: Avital Gilam, João Conde, João Conde, Daphna Weissglas-Volkov, Nuria Oliva, Eitan Friedman, Natalie ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
Biodegradable polymer nanocarriers for therapeutic antisense microRNA delivery in living animals. SPIE BiOS, International Society for Optics and Photonics. 2012:823208–823213. [126] Babar IA, Cheng CJ, Booth CJ, Liang X, Weidhaas JB, Saltzman WM, Slack FJ. Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model ...Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://pubs.acs.org/doi/10.1021/mp2002076
MicroRNA delivery with osmotic polysorbitol-based transporter suppresses breast cancer cell proliferation. International Journal of Biological Macromolecules 2015, 72, 1237-1243. DOI: 10.1016/j.ijbiomac.2014.10.041. Volker Baumann, Johannes Winkler.Author: Yun Wu, Melissa Crawford, Bo Yu, Yicheng Mao, Serge P. Nana-Sinkam, L. James Lee
https://www.hindawi.com/journals/ije/2019/6782653/
Emerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are essential for bone remodeling and regeneration. Undoubtedly, microRNA-based gene therapies show great potential to become novel approaches against bone-related diseases, including osteoporosis and associated fractures. The major obstacles for continued advancement of microRNA …Author: Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo
https://link.springer.com/article/10.1007/s40820-019-0310-0
Sep 25, 2019 · Nanosized cytotoxic drug could combat against the autophagy induced by the drug. The drug nanorods enabled efficient intracellular delivery of the nucleic acid and the resultant autophagy inhibition in vitro and in vivo, which in turn sensitized the cancer cells to the anti-tumor nanorods. Nanosized cytotoxic drug could combat against the autophagy induced by the drug. The drug …Author: Xiaofei Xin, Xiaoqing Du, Qingqing Xiao, Helena S. Azevedo, Wei He, Lifang Yin
http://news.mit.edu/2015/microrna-shrink-tumor-cancer-treatment-1207
Dec 07, 2015 · This delivery technique will likely work best with accessible solid tumors, such as breast, colon, and possibly brain tumors, Artzi says. This type of microRNA therapy could also be used to prevent tumors from spreading throughout the body. Several microRNA sequences have already been found to play a role in this process, known as metastasis.
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