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https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Transdermal drug delivery system is an emerging area for systemic as well as local delivery of macromolecules. The biggest drawback of TDDS is poor permeability through stratum corneum and it can be overcome by using microneedles.Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
https://www.sciencedirect.com/science/article/pii/S0753332218348091
Combination of ultrasound and transdermal drug delivery is also studied in order to further increase the drug permeability . Thus, microneedles can be fabricated with a variety of modifications in order to smartly deliver the drug through the skin providing a new direction and revolution in the field of transdermal drug delivery systems.Author: Tejashree Waghule, Gautam Singhvi, Sunil Kumar Dubey, Murali Monohar Pandey, Gaurav Gupta, Mahaveer ...
https://www.researchgate.net/publication/51860989_Microneedles_An_Emerging_Transdermal_Drug_Delivery_System
drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by c onventional transdermal techniques.
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
Images of microneedles used for transdermal drug delivery. (a) Solid microneedles (150 μm tall) etched from a silicon wafer were used in the first study to demonstrate microneedles for transdermal delivery. (b) Solid microneedles (1000 μm tall) laser-cut from a stainless steel sheet were used to …Author: Mark R Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794664/
Oct 14, 2019 · Microneedles are convenient, safe, and painless enough to achieve the comfort of patient and now widely used in transdermal, ocular, and intracellular delivery. 10,12,34,131 Hereinto, transdermal drug delivery is the main area for the application of MNs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
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