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https://onlinelibrary.wiley.com/doi/abs/10.1002/9783527814633.ch10
Transdermal drug delivery includes application of drug(s) to the skin for systemic effects. However, relatively few drugs possess the requisite characteristics to passively traverse the skin's stratum corneum barrier. Microneedle (MN) technology is a novel drug delivery technology that increases skin permeability by creating microscopic pores within the skin through which the passive drug diffusion to …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119996/
Dec 18, 2013 · The first strategy of MN-mediated transdermal and dermal drug delivery is via the use of solid MN, also termed the “poke with patch” approach (Prausnitz, 2004).Upon removal of the MN, transient microchannels are created in the skin upon which a conventional drug formulation is subsequently applied.Author: Tuan-Mazlelaa Tuan-Mahmood, Maelíosa T.C. McCrudden, Barbara M. Torrisi, Emma McAlister, Martin J. G...
https://www.dermarollershop.com/blog/microneedles-transdermal-drug-delivery-dynamic-duo/
One of the major uses of microneedles is transdermal drug delivery. But the success of this route has severely limited by the inability of some medications to enter the skin at a therapeutically useful rate. Just recently, there is an increasing use of micron-scale needles in increasing the skin permeability.
https://www.tandfonline.com/doi/abs/10.1080/13543776.2020.1742324
Transdermal drug delivery systems have been overcoming conventional administration because it can prevent drug degradation, and also improve the bioavailability and provide sustained drug release. Microneedles are a painless technology for drug delivery into skin and cannot cause any discomfort and cross-infection compared to traditional needle stick injuries, allowing patient compliance to the …
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Microneedles can be defined as solid (Figure 2a–d) or hollow (Figure 2e) cannula with an approximate length of 50–900 µm and an external diameter of not more than 300 µm.18 Microneedles can be fabricated within a patch for transdermal drug delivery.Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · Chen et al. also prepared a microneedle transdermal delivery system, composed of embeddable chitosan microneedles and a poly(l-lactide-co-d, l-lactide) (PLA) supporting array and used the microneedles for complete and sustained delivery of encapsulated antigens to the skin . Chitosan microneedles were mounted to the top of a strong PLA supporting array, providing mechanical strength to fully insert the microneedles …Author: Kevin B. Ita
https://www.sciencedirect.com/science/article/pii/S0169409X18300231
However, the clinical application of transdermal delivery had been limited to lipophilic drugs with a molecular weight less than 500 Da [, , ] until the emergence of polymeric microneedles (MNs), which provides a broad and versatile platform to overcome the challenges of …Author: Yanqi Ye, Jicheng Yu, Di Wen, Anna R. Kahkoska, Zhen Gu
http://drugdelivery.chbe.gatech.edu/Papers/2007/Gill%20J%20Control%20Release%202007.pdf
Keywords: Dip-coating method; Microfabricated microneedles; Transdermal drug delivery 1. Introduction Biopharmaceuticals, such as peptides, proteins and future uses of DNA and RNA, represent a rapidly growing segment of pharmaceutical therapies [1]. These biotechnology drugs are currently delivered almost exclusively by the parenteral route.
https://www.medicaldesignandoutsourcing.com/microneedle-technology-transdermal-drug-delivery/
Jun 23, 2016 · One obvious benefit of transdermal microneedle delivery is that it reduces the need for hypodermic injections. Although they’re effective, hypodermic needles can cause discomfort, bruising, and even hypersensitivity at the injection site.
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